Product nameAnti-Mib1/Mindbomb antibody
See all Mib1/Mindbomb primary antibodies
DescriptionRabbit polyclonal to Mib1/Mindbomb
Tested applicationsSuitable for: WB, ICC, IHC-Frmore details
Species reactivityReacts with: Drosophila melanogaster
Synthetic peptide derived from the N terminal domain of Drosophila melanogaster (Fruit fly) Mib1/Mindbomb.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: Whole serum
Our Abpromise guarantee covers the use of ab74134 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 130 kDa.|
|ICC||Use at an assay dependent concentration.|
|IHC-Fr||1/50 - 1/100.|
FunctionE3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Tissue specificityWidely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesContains 9 ANK repeats.
Contains 2 MIB/HERC2 domains.
Contains 3 RING-type zinc fingers.
Contains 1 ZZ-type zinc finger.
modificationsUbiquitinated. Possibly via autoubiquitination.
Cellular localizationCytoplasm. Cell membrane. Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear.
- Information by UniProt
- DAPK-interacting protein 1 antibody
- Dip 1 antibody
- DIP-1 antibody
ab74134 has not yet been referenced specifically in any publications.