Key features and details
- Ca2+ channel blocker
- CAS Number: 116666-63-8
- Purity: > 98%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameMibefradil dihydrochloride, Ca2+ channel blocker
DescriptionCa2+ channel blocker
Biological descriptionCa2+ channel blocker. Shows moderate selectivity for T-type channels (IC50 values are 2.7 and 18.6 μM for T-type and L-type respectively). Shows antihypertensive effects in vivo. Orally active.
Chemical name(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetate dihydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120343 has been referenced in 4 publications.
- Cerina M et al. Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing. Br J Pharmacol 172:3126-40 (2015). PubMed: 25684311
- Bancila M et al. Two structurally different T-type Ca 2+ channel inhibitors, mibefradil and pimozide, protect CA1 neurons from delayed death after global ischemia in rats. Fundam Clin Pharmacol 25:469-78 (2011). PubMed: 21039820
- Major TC et al. The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay. J Pharmacol Exp Ther 325:723-31 (2008). PubMed: 18326812
- Clozel JP et al. Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J Hypertens Suppl 15:S17-25 (1997). PubMed: 9481612