Mibefradil dihydrochloride, Ca2+ channel blocker (ab120343)

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Overview

  • Product name

    Mibefradil dihydrochloride, Ca2+ channel blocker

  • Description

    Ca2+ channel blocker

  • Biological description

    Ca2+ channel blocker. Shows moderate selectivity for T-type channels (IC50 values are 2.7 and 18.6 μM for T-type and L-type respectively). Shows antihypertensive effects in vivo. Orally active.

  • Purity

    > 98%

  • CAS Number

    116666-63-8

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetate dihydrochloride

  • Molecular weight

    568.56

  • Molecular formula

    C29H38FN3O3.2HCl

  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in water to 50 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cl.CC(C)[C@H]4c5ccc(F)cc5CC[C@]4(OC(=O)C1CC1)CCN(C)CCCc2nc3ccccc3n2

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wang J  et al. Ca(2+) influx mediates the TRPV4-NO pathway in neuropathic hyperalgesia following chronic compression of the dorsal root ganglion. Neurosci Lett 588:159-65 (2015). Read more (PubMed: 25575793) »
  • Fernández-Morales JC  et al. Blockade by NNC 55-0396, mibefradil, and nickel of calcium and exocytotic signals in chromaffin cells: implications for the regulation of hypoxia-induced secretion at early life. Eur J Pharmacol 751:1-12 (2015). Read more (PubMed: 25622555) »
  • Osterrieder W & Holck M In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action. J Cardiovasc Pharmacol 13:754-9 (1989). Read more (PubMed: 2472524) »
See all 3 Publications for this product

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