Overview

  • Product name

    Anti-MICB antibody [3C37]
    See all MICB primary antibodies
  • Description

    Mouse monoclonal [3C37] to MICB
  • Host species

    Mouse
  • Tested applications

    Suitable for: Flow Cyt, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human MICB aa 23-307. (NP_005922.2).
    Database link: Q29980

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Constituent: 100% PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    3C37
  • Isotype

    IgG2
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab196549 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 43 kDa.

Target

  • Function

    Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
  • Tissue specificity

    Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
  • Involvement in disease

    Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=The MICB*004 allele is associated with rheumatoid arthritis.
    Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
  • Sequence similarities

    Belongs to the MHC class I family. MIC subfamily.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Post-translational
    modifications

    Proteolytically cleaved and released from the cell surface of tumor cells.
  • Cellular localization

    Cell membrane. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
  • Information by UniProt
  • Database links

  • Alternative names

    • MHC class I chain related protein B antibody
    • MHC class I chain related protein B2 antibody
    • MHC class I like molecule PERB11.2 IMX antibody
    • MHC class I mic B antigen antibody
    • MHC class I polypeptide related sequence B antibody
    • MHC class I polypeptide-related sequence B antibody
    • MIC B antibody
    • MIC-B antibody
    • MICB antibody
    • MICB_HUMAN antibody
    • PERB11.2 antibody
    • Stress inducible class I homolog antibody
    see all

References

ab196549 has not yet been referenced specifically in any publications.

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