Mifepristone (RU486), Progesterone and Glucocorticoid receptor antagonist (ab120356)
- Datasheet
- References (2)
Overview
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Product name
Mifepristone (RU486), Progesterone and Glucocorticoid receptor antagonist -
Description
PR and GR antagonist -
Alternative names
- RU486
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Biological description
A cell-permeable synthetic steroid that acts as a potent selective antagonist of progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Acts as a silent antagonist at PR and has a higher affinity than progesterone. -
Purity
> 99% -
CAS Number
84371-65-3 -
Chemical structure
Properties
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Chemical name
(11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one -
Molecular weight
429.60 -
Molecular formula
C29H35NO2 -
PubChem identifier
55245 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)c1ccc(cc1)[C@H]4C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]5CCC3=CC(=O)CCC3=C45 -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Mao J et al. Molecular mechanism of RU 486 action: a review. Mol Cell Biochem 109:1-8 (1992). Read more (PubMed: 1614417) »
- Gagne D et al. RU 38486: a potent antiglucocorticoid in vitro and in vivo. J Steroid Biochem 23:247-51 (1985). Read more (PubMed: 2864478) »
- Baulieu EE The antisteroid RU486: its cellular and molecular mode of action. Trends Endocrinol Metab 2:233-9 (0). Read more (PubMed: 18411188) »
