Overview

  • Product name

  • Description

    Rabbit polyclonal to MIG-6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human MIG-6 (internal sequence). NP_061821.
    Database link: Q9UJM3

  • Positive control

    • Human liver cancer tissue; Human brain malignant glioma tissue lysate; HepG2 whole cell lysate (ab7900)

Properties

Applications

Our Abpromise guarantee covers the use of ab198834 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.
WB 1/200 - 1/1000. Predicted molecular weight: 51 kDa.

Target

  • Function

    Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.
  • Sequence similarities

    Belongs to the MIG6 family.
  • Domain

    The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer.
  • Cellular localization

    Cytoplasm. Cell membrane. Nucleus. Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.
  • Information by UniProt
  • Database links

  • Alternative names

    • ERBB receptor feedback inhibitor 1 antibody
    • ERRFI_HUMAN antibody
    • Errfi1 antibody
    • GENE 33 antibody
    • Gene 33, rat, homolog of antibody
    • Mig-6 antibody
    • MIG6 antibody
    • mitogen inducible gene 6 antibody
    • mitogen inducible gene 6 protein antibody
    • Mitogen-inducible gene 6 protein antibody
    • RALT antibody
    • receptor-associated late transducer antibody
    see all

Images

  • All lanes : Anti-MIG-6 antibody (ab198834) at 1/400 dilution

    Lane 1 : Human brain malignant glioma tissue lysate
    Lane 2 : HepG2 cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 51 kDa


    Exposure time: 5 minutes


    8% SDS-PAGE

  • Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling MIG-6 with ab198834 at 1/35 dilution.

References

This product has been referenced in:

  • Cairns J  et al. Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation. EMBO Rep 19:N/A (2018). Read more (PubMed: 29335246) »
See 1 Publication for this product

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