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Neuroscience Cell Adhesion Proteins Membrane Proteins
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Anti-MIIP antibody (ab167197)

  • Datasheet
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Abpromise

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Find out more.

Western blot - Anti-MIIP antibody (ab167197)

    Key features and details

    • Mouse polyclonal to MIIP
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Mouse IgG H&L (HRP) (ab205719)

    View more associated products

    Overview

    • Product name

      Anti-MIIP antibody
      See all MIIP primary antibodies
    • Description

      Mouse polyclonal to MIIP
    • Host species

      Mouse
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Human
    • Immunogen

      Recombinant full length protein, corresponding to amino acids 1-388 of Human MIIP (AAH08068.1).

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Lysate of 293T cells transfected with MIIP.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
    • Storage buffer

      pH: 7.4
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Protein A purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Cell Adhesion Proteins
      • Membrane Proteins
      • Neuroscience
      • Cell Adhesion Proteins
      • Cytoskeletal Proteins
      • Regulation
      • Cancer
      • Invasion/microenvironment
      • ECM
      • Cell adhesion
      • Other

    Associated products

    • Compatible Secondaries

      • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
      • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
    • Isotype control

      • Mouse IgG - Isotype Control (ab37355)

    Applications

    Our Abpromise guarantee covers the use of ab167197 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa.

    Target

    • Relevance

      MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway.
    • Database links

      • Entrez Gene: 60672 Human
      • Omim: 608772 Human
      • SwissProt: Q5JXC2 Human
      • Unigene: 8595 Human
      • Alternative names

        • FLJ12438 antibody
        • FLJ38609 antibody
        • IGFBP 2 binding protein antibody
        • IGFBP2 binding protein antibody
        • IIP45 antibody
        • Invasion inhibitory protein 45 antibody
        • Migration and invasion inhibitory protein antibody
        • RP5 1077B9.4 antibody
        see all

      Images

      • Western blot - Anti-MIIP antibody (ab167197)
        Western blot - Anti-MIIP antibody (ab167197)
        All lanes : Anti-MIIP antibody (ab167197) at 1 µg/ml

        Lane 1 : Lysate of 293T cells transfected with MIIP
        Lane 2 : Lysate of 293T cells (non-transfected)

        Lysates/proteins at 15 µl per lane.

        Secondary
        All lanes : Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

        Predicted band size: 43 kDa

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab167197? Please let us know so that we can cite the reference in this datasheet.

      ab167197 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

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