Overview

  • Product name

  • Description

    Rabbit polyclonal to Mimitin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Fusion protein corresponding to Human Mimitin (internal sequence). The identity of the protein fusion partner is GST.
    Database link: Q8N183

  • Positive control

    • Human liver cancer tissue lysate; Raji and HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab198198 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 20 kDa.

Target

  • Function

    Acts as a molecular chaperone for mitochondrial complex I assembly.
  • Tissue specificity

    Highly expressed in ESCC cells. Also expressed in heart, skeletal muscle, liver, and in fibroblasts.
  • Involvement in disease

    Defects in NDUFAF2 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
  • Sequence similarities

    Belongs to the complex I NDUFA12 subunit family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • B17.2 like antibody
    • B17.2-like antibody
    • B17.2L antibody
    • FLJ22398 antibody
    • MIMIT_HUMAN antibody
    • Mimitin antibody
    • Mimitin mitochondrial antibody
    • mitochondrial antibody
    • MMTN antibody
    • Myc induced mitochondrial protein antibody
    • Myc-induced mitochondrial protein antibody
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 2 antibody
    • NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 antibody
    • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 antibody
    • NDUFA12 like antibody
    • NDUFA12 like protein antibody
    • NDUFA12-like protein antibody
    • NDUFA12L antibody
    • NDUFAF2 antibody
    • OTTHUMP00000161882 antibody
    • OTTHUMP00000221703 antibody
    see all

Images

  • All lanes : Anti-Mimitin antibody (ab198198) at 1/250 dilution

    Lane 1 : Raji cell lysate
    Lane 2 : Human liver cancer tissue lysate
    Lane 3 : HeLa cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 20 kDa


    Exposure time: 10 seconds


    10% SDS-PAGE

References

ab198198 has not yet been referenced specifically in any publications.

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