Mithramycin A (Plicamycin), DNA and RNA polymerase inhibitor (ab142723)

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Overview

  • Product name

    Mithramycin A (Plicamycin), DNA and RNA polymerase inhibitor

  • Description

    DNA and RNA polymerase inhibitor. DNA binding transciptional inhibitor.

  • Biological description

    DNA and RNA polymerase inhibitor, DNA binding transcriptional inhibitor (Sp1 and Sp3). Shows antineoplastic activity.

  • Purity

    > 97%

  • CAS Number

    18378-89-7

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[4-[4-(4,5-Dihydroxy-4,6-dimethyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-3-(3,4-dihydroxy-1-methoxy-2-oxopentyl)-6-[4-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-8,9-dihydroxy-7-methyl-3,4-dihydro-2H-anthracen-1-one

  • Molecular weight

    1084.47

  • Molecular formula

    C52H76O24

  • PubChem identifier

    163659

  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in ethanol

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jia Z  et al. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res 70:1111-9 (2010). Read more (PubMed: 20086170) »
  • Chatterjee S  et al. Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons. Ann Neurol 49:345-54 (2001). Read more (PubMed: 11261509) »
  • Cheung WK  et al. Changes in tissue concentrations of 14C-doxorubicin caused by mitoxantrone, mithramycin A and vinblastine in the rat. Res Commun Chem Pathol Pharmacol 59:61-8 (1988). Read more (PubMed: 2965402) »
See 1 Publication for this product

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