Key features and details
- DNA and RNA polymerase inhibitor. DNA binding transciptional inhibitor.
- CAS Number: 18378-89-7
- Purity: > 98%
- Soluble in ethanol to 5 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameMithramycin A (Plicamycin), DNA and RNA polymerase inhibitor
DescriptionDNA and RNA polymerase inhibitor. DNA binding transciptional inhibitor.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 5 mM and in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142723 has been referenced in 4 publications.
- Zhou Q et al. The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-a/IL-33/ST2L signaling promotes gastric cancer metastasis. Oncogene 39:1414-1428 (2020). PubMed: 31659258
- Huang C et al. Drug-Eluting Stent Targeting Sp-1-Attenuated Restenosis by Engaging YAP-Mediated Vascular Smooth Muscle Cell Phenotypic Modulation. J Am Heart Assoc 9:e014103 (2020). PubMed: 31880978
- Zhang H et al. Sp4 controls constitutive expression of neuronal serine racemase and NF-E2-related factor-2 mediates its induction by valproic acid. Biochim Biophys Acta Gene Regul Mech 1863:194597 (2020). PubMed: 32603878
- Yamaguchi R et al. Transcription factor specificity protein 1 modulates TGFß1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P. Cytokine 108:24-36 (2018). PubMed: 29558695