Mithramycin A (Plicamycin), DNA and RNA polymerase inhibitor (ab142723)
Key features and details
- DNA and RNA polymerase inhibitor. DNA binding transciptional inhibitor.
- CAS Number: 18378-89-7
- Purity: > 98%
- Soluble in ethanol to 5 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mithramycin A (Plicamycin), DNA and RNA polymerase inhibitor -
Description
DNA and RNA polymerase inhibitor. DNA binding transciptional inhibitor. -
Purity
> 98% -
CAS Number
18378-89-7 -
Chemical structure
Properties
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Chemical name
2-[4-[4-(4,5-Dihydroxy-4,6-dimethyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-3-(3,4-dihydroxy-1-methoxy-2-oxopentyl)-6-[4-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-8,9-dihydroxy-7-methyl-3,4-dihydro-2H-anthracen-1-one -
Molecular weight
1084.47 -
Molecular formula
C52H76O24 -
PubChem identifier
163659 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 5 mM and in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Mithramycin A (Plicamycin), DNA and RNA polymerase inhibitor (ab142723)2D chemical structure image of ab142723, Mithramycin A (Plicamycin), DNA and RNA polymerase inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab142723 has been referenced in 5 publications.
- Zhou Q et al. The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-a/IL-33/ST2L signaling promotes gastric cancer metastasis. Oncogene 39:1414-1428 (2020). PubMed: 31659258
- Huang C et al. Drug-Eluting Stent Targeting Sp-1-Attenuated Restenosis by Engaging YAP-Mediated Vascular Smooth Muscle Cell Phenotypic Modulation. J Am Heart Assoc 9:e014103 (2020). PubMed: 31880978
- Zhang H et al. Sp4 controls constitutive expression of neuronal serine racemase and NF-E2-related factor-2 mediates its induction by valproic acid. Biochim Biophys Acta Gene Regul Mech 1863:194597 (2020). PubMed: 32603878
- Yan X et al. VIP Induces Changes in the F-/G-Actin Ratio of Schlemm's Canal Endothelium via LRRK2 Transcriptional Regulation. Invest Ophthalmol Vis Sci 61:45 (2020). PubMed: 32572455
- Yamaguchi R et al. Transcription factor specificity protein 1 modulates TGFß1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P. Cytokine 108:24-36 (2018). PubMed: 29558695