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ab57602 has been referenced in 89 publications.

  • Hou X  et al. Mitofusin1 in oocyte is essential for female fertility. Redox Biol 21:101110 (2019). PubMed: 30690319
  • Yen JH  et al. Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone. J Exp Clin Cancer Res 38:42 (2019). PubMed: 30691497
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  • Ma S & Dong Z Melatonin Attenuates Cardiac Reperfusion Stress by Improving OPA1-Related Mitochondrial Fusion in a Yap-Hippo Pathway-Dependent Manner. J Cardiovasc Pharmacol 73:27-39 (2019). PubMed: 30418242
  • Wei N  et al. Therapeutic effects of melatonin on cerebral ischemia reperfusion injury: Role of Yap-OPA1 signaling pathway and mitochondrial fusion. Biomed Pharmacother 110:203-212 (2019). PubMed: 30476721
  • Li H  et al. Mst1 deletion attenuates renal ischaemia-reperfusion injury: The role of microtubule cytoskeleton dynamics, mitochondrial fission and the GSK3ß-p53 signalling pathway. Redox Biol 20:261-274 (2019). PubMed: 30384260
  • Nakazawa H  et al. Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle. FEBS Open Bio 9:348-363 (2019). PubMed: 30761259
  • MacMillan-Crow LA & Mayeux PR Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis. Intern Med Rev (Wash D C) 4:N/A (2018). PubMed: 30506014
  • Lu C  et al. TNFa promotes glioblastoma A172 cell mitochondrial apoptosis via augmenting mitochondrial fission and repression of MAPK-ERK-YAP signaling pathways. Onco Targets Ther 11:7213-7227 (2018). PubMed: 30425514
  • Huang X  et al. CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10. Hum Mol Genet 27:3881-3900 (2018). PubMed: 30084972
  • de Las Heras N  et al. Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue. Front Physiol 9:1122 (2018). PubMed: 30174613
  • Pabón MA  et al. Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease. JCI Insight 3:N/A (2018). PubMed: 30232271
  • De R  et al. Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-?B signaling. J Biol Chem 293:19740-19760 (2018). PubMed: 30366984
  • Hamilton S  et al. Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species. Front Physiol 9:1831 (2018). PubMed: 30622478
  • Tsushima K  et al. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. Circ Res 122:58-73 (2018). PubMed: 29092894
  • Sato Y  et al. Apobec2 deficiency causes mitochondrial defects and mitophagy in skeletal muscle. FASEB J 32:1428-1439 (2018). PubMed: 29127187
  • Chen D  et al. A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues. J Cell Biochem 119:9602 (2018). PubMed: 30171706
  • Qin N  et al. UCP2-dependent improvement of mitochondrial dynamics protects against acute kidney injury. J Pathol N/A:N/A (2018). PubMed: 30426490
  • Ding X  et al. IL-2 augments the sorafenib-induced apoptosis in liver cancer by promoting mitochondrial fission and activating the JNK/TAZ pathway. Cancer Cell Int 18:176 (2018). PubMed: 30459526
  • Baardman J  et al. A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia. Cell Rep 25:2044-2052.e5 (2018). PubMed: 30463003
  • Tyagi A  et al. SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep 8:17547 (2018). PubMed: 30510203
  • Wu MJ  et al. Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin. Cell Metab N/A:N/A (2018). PubMed: 30527740
  • Ryan ZC  et al. 1a,25-dihydroxyvitamin D3mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells. Biochem Biophys Res Commun 496:746-752 (2018). WB . PubMed: 29366785
  • Leipnitz G  et al. Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency. Sci Rep 8:1165 (2018). WB ; Human . PubMed: 29348607
  • Bartolome F  et al. Amyloid ß-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition. Alzheimers Res Ther 10:24 (2018). WB . PubMed: 29458418
  • Hagenbuchner J  et al. Very long-/ and long Chain-3-Hydroxy Acyl CoA Dehydrogenase Deficiency correlates with deregulation of the mitochondrial fusion/fission machinery. Sci Rep 8:3254 (2018). WB ; Human . PubMed: 29459657
  • Marín-Royo G  et al. Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity. Dis Model Mech 11:N/A (2018). PubMed: 29361517
  • Pansarasa O  et al. Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms. Dis Model Mech 11:N/A (2018). PubMed: 29419416
  • Tetri LH  et al. Sex-Specific Skeletal Muscle Fatigability and Decreased Mitochondrial Oxidative Capacity in Adult Rats Exposed to Postnatal Hyperoxia. Front Physiol 9:326 (2018). WB ; Rat . PubMed: 29651255
  • Lobet E  et al. Mitochondrial fragmentation affects neither the sensitivity to TNFa-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria. Sci Rep 8:5173 (2018). WB ; Mouse . PubMed: 29581535
  • Mizuno M  et al. Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts. Physiol Rep 6:e13741 (2018). PubMed: 29932506
  • Kriel J  et al. Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics. Sci Rep 8:10348 (2018). PubMed: 29985441
  • Yamada T  et al. Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease. Cell Metab N/A:N/A (2018). PubMed: 30017357
  • Wang Q  et al. Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L. Autophagy 13:404-422 (2017). PubMed: 28085543
  • Ando M  et al. The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity. Mol Neurodegener 12:32 (2017). PubMed: 28438176
  • Su L  et al. Activation of transient receptor potential vanilloid 1 accelerates re-endothelialization and inhibits neointimal formation after vascular injury. J Vasc Surg 65:197-205.e2 (2017). PubMed: 26947234
  • Warren JL  et al. Effects of acute hyperinsulinemia on skeletal muscle mitochondrial function, reactive oxygen species production, and metabolism in premenopausal women. Metabolism 77:1-12 (2017). PubMed: 29132536
  • Steffen J  et al. Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria. Mol Biol Cell 28:600-612 (2017). WB ; Human . PubMed: 28057766
  • Tezze C  et al. Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. Cell Metab 25:1374-1389.e6 (2017). PubMed: 28552492
  • Vishnyakova PA  et al. Alterations in antioxidant system, mitochondrial biogenesis and autophagy in preeclamptic myometrium. BBA Clin 8:35-42 (2017). PubMed: 28736722
  • Hsu JY  et al. The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models. Front Mol Neurosci 10:196 (2017). PubMed: 28676741
  • Zhou H  et al. Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission. Redox Biol 15:335-346 (2017). PubMed: 29306791
  • Fiesel FC  et al. Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy. Oncotarget 8:106233-106248 (2017). PubMed: 29290944
  • Huang ZN  et al. Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects. Int J Biol Sci 13:1420-1437 (2017). PubMed: 29209146
  • Cowan DB  et al. Transit and integration of extracellular mitochondria in human heart cells. Sci Rep 7:17450 (2017). PubMed: 29234096
  • Tarpey MD  et al. Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal. Mol Metab 6:1597-1609 (2017). PubMed: 29097020
  • Vo MT  et al. Tristetraprolin inhibits mitochondrial function through suppression of a-Synuclein expression in cancer cells. Oncotarget 8:41903-41920 (2017). PubMed: 28410208
  • Tang K  et al. Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy. J Am Heart Assoc 6:N/A (2017). PubMed: 28432072
  • Parajuli N  et al. Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLoS One 12:e0185542 (2017). PubMed: 28977005
  • Pereira RO  et al. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J 36:2126-2145 (2017). PubMed: 28607005
  • Jugé R  et al. Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes. Sci Rep 6:35065 (2016). PubMed: 27731355
  • Berezhnov AV  et al. Intracellular pH Modulates Autophagy and Mitophagy. J Biol Chem 291:8701-8 (2016). PubMed: 26893374
  • Sirianni A  et al. Mitochondria mediate septin cage assembly to promote autophagy of Shigella. EMBO Rep 17:1029-43 (2016). PubMed: 27259462
  • Lucas E  et al. Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels. Cardiovasc Diabetol 15:155 (2016). WB . PubMed: 27832814
  • Cheng M  et al. MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis. Oncotarget 7:42274-42287 (2016). WB . PubMed: 27281615
  • Agarwal S  et al. Dynamin-related Protein 1 Inhibition Mitigates Bisphenol A-mediated Alterations in Mitochondrial Dynamics and Neural Stem Cell Proliferation and Differentiation. J Biol Chem 291:15923-39 (2016). WB ; Rat . PubMed: 27252377
  • Malhotra A  et al. Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma. Mol Cancer Res 14:114-24 (2016). WB ; Mouse . PubMed: 26446920
  • Joshi SR  et al. MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol 311:H689-98 (2016). PubMed: 27422986
  • Hall AR  et al. Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction. Cell Death Dis 7:e2238 (2016). WB ; Mouse . PubMed: 27228353
  • Philley JV  et al. Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression. J Cell Physiol 231:1364-74 (2016). PubMed: 26530043
  • Newell C  et al. Tissue Specific Impacts of a Ketogenic Diet on Mitochondrial Dynamics in the BTBR(T+tf/j) Mouse. Front Physiol 7:654 (2016). WB . PubMed: 28082920
  • Onesto E  et al. Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts. Acta Neuropathol Commun 4:47 (2016). WB . PubMed: 27151080
  • Norkett R  et al. DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites. J Biol Chem 291:613-29 (2016). PubMed: 26553875
  • Ayanga BA  et al. Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy. J Am Soc Nephrol 27:2733-47 (2016). PubMed: 26825530
  • Asencio C  et al. Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q10 content. Eur J Hum Genet 24:367-72 (2016). PubMed: 26014431
  • Ryan ZC  et al. 1a,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells. J Biol Chem 291:1514-28 (2016). PubMed: 26601949
  • Mukherjee R & Chakrabarti O Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis. J Cell Sci 129:757-73 (2016). PubMed: 26743086
  • Li L  et al. p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility. Mol Biol Cell 26:3828-40 (2015). Human . PubMed: 26337390
  • Ikeda Y  et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res 116:264-78 (2015). PubMed: 25332205
  • Wu SP  et al. Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun 6:8245 (2015). PubMed: 26356605
  • Song M  et al. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab 21:273-85 (2015). PubMed: 25600785
  • Wang C  et al. Dynamic tubulation of mitochondria drives mitochondrial network formation. Cell Res 25:1108-20 (2015). PubMed: 26206315
  • Zhang J  et al. EglN2 associates with the NRF1-PGC1a complex and controls mitochondrial function in breast cancer. EMBO J 34:2953-70 (2015). PubMed: 26492917
  • Fiesel FC  et al. (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. EMBO Rep 16:1114-30 (2015). PubMed: 26162776
  • Stauch KL  et al. Quantitative proteomics of synaptic and nonsynaptic mitochondria: insights for synaptic mitochondrial vulnerability. J Proteome Res 13:2620-36 (2014). PubMed: 24708184
  • MacVicar TD & Lane JD Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation. J Cell Sci 127:2313-25 (2014). PubMed: 24634514
  • Yun J  et al. MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife (Cambridge) 3:e01958 (2014). WB ; Human . PubMed: 24898855
  • Fiesel FC  et al. A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently. J Cell Sci 127:3488-504 (2014). PubMed: 24928900
  • Neary MT  et al. Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function. J Mol Cell Cardiol 74:340-52 (2014). WB . PubMed: 24984146
  • Stauch KL  et al. Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function. Aging (Albany NY) 6:320-34 (2014). WB . PubMed: 24827396
  • Tasseva G  et al. Phosphatidylethanolamine deficiency in Mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology. J Biol Chem 288:4158-73 (2013). WB . PubMed: 23250747
  • Mancini C  et al. Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. BMC Med Genomics 6:22 (2013). WB ; Human . PubMed: 23777634
  • Guo X  et al. Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J Clin Invest 123:5371-88 (2013). WB ; Mouse . PubMed: 24231356
  • Burchell VS  et al. The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci 16:1257-65 (2013). PubMed: 23933751
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