Key features and details
- Ratiometric, fluorescent, mitochondria-targeted lipid peroxidation probe
- Purity: > 95%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameMitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe
DescriptionRatiometric, fluorescent, mitochondria-targeted lipid peroxidation probe
Ratiometric, fluorescent, mitochondria-targeted lipid peroxidation probe. Derived from the C11-BODIPY(581/591) probe, which contains a boron dipyromethane difluoride (BODIPY) fluorophore conjugated via a dienyl link to a phenyl group. An attached triphenylphosphonium lipophilic cation leads to selective uptake into mitochondria in living cells, driven by the mitochondrial membrane potential. In response to lipid peroxidation the fluorescence emission maximum shifts from ∼590 to ∼520 nm.
Chemical name4,4-Difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-(propionylaminoethylentriphenylphosphonium) bromide
Storage instructionsStore at -20°C long term. Store In the Dark.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146820 has been referenced in 1 publication.
- Shekhova E et al. Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus. Antimicrob Agents Chemother 61:N/A (2017). PubMed: 28848005