Key features and details
- Selective, mitochondria-targeted redox cycler
- CAS Number: 1821370-28-8
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameMitoPQ, mitochondria-targeted redox cycler
DescriptionSelective, mitochondria-targeted redox cycler
Selective, mitochondria-targeted redox cycler. Selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo. Comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.
Storage instructionsShipped at 4°C. Store at +4°C. Store under desiccating conditions.
Solubility overviewSoluble in ethanol to 10 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146819 has been referenced in 6 publications.
- Estfanous S et al. Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo. Sci Rep 11:855 (2021). PubMed: 33441602
- Bogacz M et al. The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes. Redox Biol 34:101547 (2020). PubMed: 32388269
- Booty LM et al. Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo. Cell Chem Biol 26:449-461.e8 (2019). PubMed: 30713096
- Mogilenko DA et al. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell 177:1201-1216.e19 (2019). PubMed: 31031005
- Arias-Mayenco I et al. Acute O2 Sensing: Role of Coenzyme QH2/Q Ratio and Mitochondrial ROS Compartmentalization. Cell Metab 28:145-158.e4 (2018). PubMed: 29887397
- Shchepinova MM et al. MitoNeoD: A Mitochondria-Targeted Superoxide Probe. Cell Chem Biol 24:1285-1298.e12 (2017). PubMed: 28890317