MitoPQ, mitochondria-targeted redox cycler (ab146819)

Overview

  • Product name

    MitoPQ, mitochondria-targeted redox cycler
  • Description

    Selective, mitochondria-targeted redox cycler
  • Alternative names

    • MitoParaquat
  • Biological description

    Selective, mitochondria-targeted redox cycler. Selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo. Comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.

  • Purity

    > 98%
  • CAS Number

    1821370-28-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Methyl-1'-[10''-(triphenylphosphonio)dec-1''-yl]-4,4'-bipyridine-1-1'-diium triiodide

  • Molecular weight

    954.48
  • Molecular formula

    C39H46I3N2P
  • Storage instructions

    Shipped at 4°C. Store at +4°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [I-].[I-].[I-].C[n+]1ccc(cc1)c5cc[n+](CCCCCCCCCC[P+](c2ccccc2)(c3ccccc3)c4ccccc4)cc5
  • Source

    Synthetic

References

This product has been referenced in:

  • Robb EL  et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radic Biol Med 89:883-94 (2015). Read more (PubMed: 26454075) »
See 1 Publication for this product

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