Overview

  • Product name

    MitoTEMPOL, mitochondria-targeted antioxidant agent
  • Description

    Mitochondria-targeted antioxidant agent
  • Biological description

    Mitochondria-targeted antioxidant agent. SOD mimetic Tempol derivative. Protects complex I and II/III respiration. Restores MnSOD activity. Shows cardioprotective effects in vivo.
  • Purity

    > 98%
  • CAS Number

    1101113-39-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,2,6,6-Tetramethyl-4-[[5-(triphenylphosphonio)pentyl]oxy]-1-piperidinyloxy bromide
  • Molecular weight

    583.57
  • Molecular formula

    C32H42BrNO2P
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Patil NK  et al. Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. Am J Physiol Renal Physiol 306:F734-43 (2014). Read more (PubMed: 24500690) »
  • Liang Y  et al. Alcohol induced mitochondrial oxidative stress and alveolar macrophage dysfunction. Biomed Res Int 2014:371593 (2014). Read more (PubMed: 24701574) »
  • Dickey JS  et al. Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. PLoS One 8:e70575 (2013). Read more (PubMed: 23940596) »
See all 3 Publications for this product

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