Overview

  • Product name
    Mitoxantrone dihydrochloride, Type II topoisomerase inhibitor
  • Description
    Type II topoisomerase inhibitor
  • Biological description
    Type II topoisomerase inhibitor (IC50 = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.
  • Purity
    > 98%
  • CAS Number
    70476-82-3
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Albertsson P  et al. Low-dosage metronomic chemotherapy and angiogenesis: topoisomerase inhibitors irinotecan and mitoxantrone stimulate VEGF-A-mediated angiogenesis. APMIS 120:147-56 (2012). Read more (PubMed: 22229270) »
  • Scott LJ & Figgitt DP Mitoxantrone: a review of its use in multiple sclerosis. CNS Drugs 18:379-96 (2004). Read more (PubMed: 15089110) »
  • Ellis AL  et al. Biochemical lesions in DNA associated with the antiproliferative effects of mitoxantrone in the hepatoma cell. Biochem Pharmacol 39:1549-56 (1990). Read more (PubMed: 2337411) »

Customer reviews and Q&As

Answer



Here is our advice regarding handling:

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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