Overview

  • Product name

    Mitoxantrone, Type II topoisomerase inhibitor
  • Description

    Type II topoisomerase inhibitor. DNA intercalating agent.
  • Biological description

    Type II topoisomerase inhibitor (IC50 = 2 μM, HepG2 cells). DNA intercalating agent. Mitoxantrone dihydrochloride (ab141041) precursor. Antineoplastic agent. Inhibits B cell, T cell, and macrophage proliferation. Inhibits antigen presentation. IL-2, TNFα and γ-interferon secretion. Shows anticancer effects in vivo.
  • Purity

    > 99%
  • CAS Number

    65271-80-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Dores-Sousa JL  et al. The age factor for mitoxantrone's cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury. Toxicology 329:106-19 (2015). Read more (PubMed: 25582955) »
  • Zaloga J  et al. Development of a lauric acid/albumin hybrid iron oxide nanoparticle system with improved biocompatibility. Int J Nanomedicine 9:4847-66 (2014). Read more (PubMed: 25364244) »
  • Workenhe ST  et al. Combining oncolytic HSV-1 with immunogenic cell death-inducing drug mitoxantrone breaks cancer immune tolerance and improves therapeutic efficacy. Cancer Immunol Res 1:309-19 (2013). Read more (PubMed: 24777969) »

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