Mivacurium chloride, nicotinic acetylcholine antagonist (ab143667)

Overview

  • Product name

    Mivacurium chloride, nicotinic acetylcholine antagonist
  • Description

    Competitive nicotinic acetylcholine antagonist
  • Biological description

    Competitive nicotinic acetylcholine antagonist. Short-acting non-depolarizing neuromuscular transmission blocker. Reversibly inhibits 5-HT3A receptors. Shows muscle relaxant effects in vivo.
  • Purity

    > 98%
  • CAS Number

    106861-44-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Bis[3-[(1R)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] (E)-oct-4-enedioate dichloride
  • Molecular weight

    1100.17
  • Molecular formula

    C58H80Cl2N2O14
  • PubChem identifier

    5281080
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C(=C3)OC)OC)OC)OC)OC)CCCOC(=O)CCC=CCCC(=O)OCCC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C(=C6)OC)OC)OC)OC)OC)C.[Cl-].[Cl-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jonsson Fagerlund M  et al. Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology 110:1244-52 (2009). Read more (PubMed: 19417616) »
  • Milchert M  et al. Skeletal muscle relaxants inhibit rat tracheal smooth muscle tone in vitro. J Physiol Pharmacol 60 Suppl 8:5-11 (2009). Read more (PubMed: 20400785) »
  • Min KT  et al. Nondepolarizing neuromuscular blockers inhibit the serotonin-type 3A receptor expressed in Xenopus oocytes. Anesth Analg 90:476-81 (2000). Read more (PubMed: 10648343) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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