Overview

  • Product name

    Mizoribine (Bredinin), Imidazole nucleoside
  • Description

    Imidazole nucleoside. Immunosuppressive agent.
  • Alternative names

    • Bredinin
  • Biological description

    Imidazole nucleoside. Immunosuppressive agent. HCV RNA replication inhibitor (IC50 = 100 μM). Inhibits T and B cell proliferation. Anti-bacterial, antiviral, antibiotic, anti-inflammatory and immunosuppressive agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    50924-49-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Fukami N  et al. Mizoribine--an inosine monophosphate dehydrogenase inhibitor--acts synergistically with cyclosporine A in prolonging survival of murine islet cell and heart transplants across major histocompatibility barrier. Transpl Immunol 26:140-5 (2012). Read more (PubMed: 22085688) »
  • Ikejiri M  et al. Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents. Bioorg Med Chem Lett 17:2470-3 (2007). Read more (PubMed: 17336519) »
  • Naka K  et al. Mizoribine inhibits hepatitis C virus RNA replication: effect of combination with interferon-alpha. Biochem Biophys Res Commun 330:871-9 (2005). Read more (PubMed: 15809077) »

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