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    mk-1775-ab147242.pdf

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Cell Biology Cell Cycle Kinases/Phosphatases Cdk Regulators
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MK-1775 (ab147242)

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  • SDS
  • COA
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Chemical Structure - MK-1775 (ab147242)

    Key features and details

    • Potent and selective small-molecule inhibitor of Wee1 kinase
    • CAS Number: 955365-80-7
    • Purity: > 98%
    • Soluble in DMSO to 200 mM

    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      MK-1775
    • Description

      Potent and selective small-molecule inhibitor of Wee1 kinase
    • Alternative names

      • AZD 1775
      • MK1775
    • Biological description

      Potent and selective small-molecule inhibitor of Wee1 kinase. Inhibits Wee1 (IC50 = 5.2 nM) in cell-free assays. Inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cell-based assays. Acts synergistically with gemcitabine in tumor cells. In a panel of 223 kinases, only 8 were inhibited >80% by 1μM MK-1775.

    • Purity

      > 98%
    • CAS Number

      955365-80-7
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo [3,4-d]pyrimidin-3-one

    • Molecular weight

      500.60
    • Molecular formula

      C27H32N8O2
    • PubChem identifier

      24856436
    • Storage instructions

      Shipped at room temperature. Store at -20°C.
    • Solubility overview

      Soluble in DMSO to 200 mM

    • Handling

      Refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
    • Source

      Synthetic

    • Research areas

      • Cell Biology
      • Cell Cycle
      • Kinases/Phosphatases
      • Cdk Regulators
      • Cell Biology
      • Cell Cycle
      • Kinases/Phosphatases
      • Other
      • Cell Biology
      • Cell Cycle
      • Cell Cycle Inhibitors
      • Other
      • Cell Biology
      • Cell Cycle
      • Cell Division
      • Spindle
      • Neuroscience
      • Neurotransmission
      • Intracellular Signaling
      • Kinases
      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Growth Cone
      • Signal Transduction
      • Protein Phosphorylation
      • Tyrosine Kinases
      • Src Family
      • Signal Transduction
      • Protein Phosphorylation
      • Tyrosine Kinases
      • Other
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • MAPK Pathway
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • Other Kinases
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • Small G Proteins
      • Ras Family
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • STATs
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • NFkB Pathway
      • Signal Transduction
      • Metabolism
      • Energy Metabolism
      • Neuroscience
      • Neurology process
      • Growth and Development
      • Axonal Guidance Proteins
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • Tyrosine Kinase Receptors
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Cancer susceptibility
      • Proto-oncogenes
      • Epigenetics and Nuclear Signaling
      • Cell cycle
      • Kinases/Phosphatases
      • Cdk Regulators
      • Epigenetics and Nuclear Signaling
      • Cell cycle
      • Kinases/Phosphatases
      • Other
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • NFkB pathway
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • STATs
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Transcription Factors
      • Cell Biology
      • Other Antibodies
      • Other Antibodies
      • Cancer
      • Cell cycle
      • Cell division
      • Cancer
      • Cell cycle
      • Cell cycle inhibitors
      • Other
      • Cancer
      • Cell cycle
      • Kinases/phosphatases
      • Other
      • Cancer
      • Signal transduction
      • Protein phosphorylation
      • Serine/threonine kinases
      • Other
      • Cancer
      • Signal transduction
      • Protein phosphorylation
      • Tyrosine kinases
      • Other
      • Cancer
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      • Oncoproteins
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      • Innate Immunity
      • TLR Signaling
      • Developmental Biology
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      • Cancer
      • Cancer Metabolism
      • Metabolic signaling pathway
      • Integration of energy metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Energy transfer pathways
      • Energy Metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Energy transfer pathways
      • Integration of energy

    Images

    • Chemical Structure - MK-1775 (ab147242)
      Chemical Structure - MK-1775 (ab147242)

      Chemical structure of MK-1775, 955365-80-7

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (0)

    Publishing research using ab147242? Please let us know so that we can cite the reference in this datasheet.

    ab147242 has not yet been referenced specifically in any publications.

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