MK-1775 (ab147242)
Key features and details
- Potent and selective small-molecule inhibitor of Wee1 kinase
- CAS Number: 955365-80-7
- Purity: > 98%
Soluble in DMSO to 200 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
MK-1775 -
Description
Potent and selective small-molecule inhibitor of Wee1 kinase -
Alternative names
- AZD 1775
- MK1775
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Biological description
Potent and selective small-molecule inhibitor of Wee1 kinase. Inhibits Wee1 (IC50 = 5.2 nM) in cell-free assays. Inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cell-based assays. Acts synergistically with gemcitabine in tumor cells. In a panel of 223 kinases, only 8 were inhibited >80% by 1μM MK-1775.
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Purity
> 98% -
CAS Number
955365-80-7 -
Chemical structure
Properties
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Chemical name
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo [3,4-d]pyrimidin-3-one
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Molecular weight
500.60 -
Molecular formula
C27H32N8O2 -
PubChem identifier
24856436 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 200 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - MK-1775 (ab147242)
Chemical structure of MK-1775, 955365-80-7
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab147242 has not yet been referenced specifically in any publications.