MK-2048, IN and INR263K inhibitor (ab231364)

Overview

  • Product name

    MK-2048, IN and INR263K inhibitor
  • Description

    Potent IN and INR263K inhibitor
  • Biological description

    MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6nM and 1.5nM respectively.

  • CAS Number

    869901-69-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (6S)-2-[(3-Chloro-4-fluorophenyl)methyl]-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-6,7-dihydropyrazino[5,6]pyrrolo[1,3-b]pyridazine-4-carboxamide

  • Molecular weight

    461.88
  • Molecular formula

    C21H21ClFN5O4
  • PubChem identifier

    54698642
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Solubility overview

    9mg/ml in DMSO

  • SMILES

    CCN1C[C@@H](N2C3=C(C(=C2C1=O)O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C
  • Source

    Synthetic

References

This product has been referenced in:

  • Quashie PK  et al. Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir. J Virol 86:2696-705 (2012). Read more (PubMed: 22205735) »
  • Bar-Magen T  et al. Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor. J Virol 84:9210-6 (2010). Read more (PubMed: 20610719) »
  • Hare S  et al. Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A 107:20057-62 (2010). Read more (PubMed: 21030679) »
  • Bar-Magen T  et al. Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes. Retrovirology 6:103 (2009). Read more (PubMed: 19906306) »

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