Potent, selective 5-HT2C receptor agonist (IC50 values are 28 and 420 nM for 5-HT2C and 5-HT2A receptors, respectively). Shows anxiogenic effects and decreases locomotor activity in vivo.
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in water to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kuznetsova EG et al. Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bull Exp Biol Med142:594-7 (2006).
Read more (PubMed: 17415471) »
de Mello Cruz AP et al. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology (Berl)182:345-54 (2005).
Read more (PubMed: 16133141) »
Hemrick-Luecke SK & Fuller RW Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212. Eur J Pharmacol311:207-11 (1996).
Read more (PubMed: 8891601) »