MK 571 sodium salt (L 660711 sodium salt), CysLT1 receptor antagonist (ab144303)

Overview

  • Product name

    MK 571 sodium salt (L 660711 sodium salt), CysLT1 receptor antagonist
  • Description

    Potent, selective and competitive CysLT1 receptor antagonist
  • Biological description

    Potent, selective and competitive CysLT1 receptor antagonist (IC50 = 1.5 nM, LTD4). Potent MRP1 inhibitor. Shows anti-ischemic, anti-inflammatory and antinociceptive effects in vivo. Orally active.
  • Purity

    > 97%
  • CAS Number

    115104-28-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[[3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoate sodium salt
  • Molecular weight

    537.07
  • Molecular formula

    C26H26ClN2NaO3S2
  • PubChem identifier

    16760569
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in water to 25 mM, in ethanol to 10 mM and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)[O-].[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wu NC  et al. MK-571 attenuates kidney ischemia and reperfusion-induced airway hypersensitivity in rats. Transplant Proc 46:1127-30 (2014). Read more (PubMed: 24815144) »
  • Magnarin M  et al. Induction of proteins involved in multidrug resistance (P-glycoprotein, MRP1, MRP2, LRP) and of CYP 3A4 by rifampicin in LLC-PK1 cells. Eur J Pharmacol 483:19-28 (2004). Read more (PubMed: 14709322) »
  • Jones TR  et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol 67:17-28 (1989). Read more (PubMed: 2540892) »

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