MK-8931, Beta-sectetase inhibitor (ab223883)

Overview

  • Product name

    MK-8931, Beta-sectetase inhibitor
  • Description

    Selective, potent Beta-sectetase inhibitor
  • Alternative names

    • Verubecestat
  • Biological description

    MK-8931 is a selective, potent Beta-sectetase 1 inhibitor (IC50 = 2.2 nM).

  • Purity

    > 98%
  • General notes

    Protect from air and light.

  • CAS Number

    1286770-55-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (R)-N-(3-(3-Amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide
  • Molecular weight

    409.41
  • Molecular formula

    C17H17F2N5O3S
  • PubChem identifier

    51352361
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark.
  • Solubility overview

    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@]1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Kennedy ME  et al. The BACE1 inhibitor verubecestat (MK-8931) reduces CNS ß-amyloid in animal models and in Alzheimer's disease patients. Sci Transl Med 8:363ra150 (2016). Read more (PubMed: 27807285) »
  • Ohno M Alzheimer's therapy targeting the ß-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies. Brain Res Bull 126:183-198 (2016). Read more (PubMed: 27093940) »
  • Yan R & Vassar R Targeting the ß secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol 13:319-29 (2014). Read more (PubMed: 24556009) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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