Product nameMK2 Kinase Inhibitor, Hsp25 Kinase (MAPKAP kinase-2) inhibitor
DescriptionSelective Hsp25 Kinase (MAPKAP kinase-2) inhibitor
- Hsp25 Kinase Inhibitor
- MAPKAP Kinase-2 Inhibitor
13-residue peptide that acts as a selective inhibitor of mammalian heat-shock protein (Hsp25) kinase [mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP kinase-2)]. Inhibition is competitive with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM).
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Yang P et al. Platelet-Derived Growth Factor Receptor-ß Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice. Crit Care Med 44:e390-402 (2016). Read more (PubMed: 26646459) »
- Katsoulidis E et al. Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes. Cancer Res 65:9029-37 (2005). Read more (PubMed: 16204077) »
- Hayess K & Benndorf R Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. Biochem Pharmacol 53:1239-47 (1997). Read more (PubMed: 9214684) »