Overview

  • Product name
    MK886, Lipoxygenase inhibitor
  • Description
    Potent lipoxygenase inhibitor
  • Biological description
    Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM). Inhibits leukotriene biosynthesis (IC50 = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.
  • Purity
    > 98%
  • CAS Number
    118414-82-7
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Cianchi F  et al. Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. Mol Cancer Ther 5:2716-26 (2006). Read more (PubMed: 17121918) »
  • Kehrer JP  et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J 356:899-906 (2001). Read more (PubMed: 11389700) »
  • Sala A  et al. Pharmacological modulation of human platelet leukotriene C4-synthase. Biochem Pharmacol 53:905-8 (1997). Read more (PubMed: 9113110) »
  • Gillard J  et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol 67:456-64 (1989). Read more (PubMed: 2548691) »

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