Anti-MKP-1 antibody (ab138265)
Key features and details
- Rabbit polyclonal to MKP-1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-MKP-1 antibody
See all MKP-1 primary antibodies -
Description
Rabbit polyclonal to MKP-1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Human MKP-1 (C terminal). Immunogen range = between aa 241-290
Database link: P28562 -
Positive control
- HepG2 whole cell lysate (ab7900)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS is without Mg2+ and Ca2+. -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab138265 was affinity purified from rabbit antiserum by immunogenic peptide affinity chromatography. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab138265 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 39 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 39 kDa. |
Target
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Function
Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'. -
Tissue specificity
Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. -
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 rhodanese domain.
Contains 1 tyrosine-protein phosphatase domain. - Information by UniProt
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Database links
- Entrez Gene: 1843 Human
- Entrez Gene: 19252 Mouse
- Entrez Gene: 114856 Rat
- Omim: 600714 Human
- SwissProt: P28562 Human
- SwissProt: P28563 Mouse
- SwissProt: Q64623 Rat
- Unigene: 171695 Human
see all -
Alternative names
- CL 100 antibody
- CL100 antibody
- Dual Specificity Phosphatase 1 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab138265 has been referenced in 4 publications.
- Lee S et al. A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biol 21:33 (2020). PubMed: 32039742
- Chen Y et al. GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12). Aging (Albany NY) 12:8858-8879 (2020). PubMed: 32439830
- Li Y et al. Clostridium difficile toxin B induces colonic inflammation through the TRIM46/DUSP1/MAPKs and NF-?B signalling pathway. Artif Cells Nanomed Biotechnol 48:452-462 (2020). PubMed: 31918570
- Almeida-Pereira G et al. 17ß-Estradiol attenuates p38MAPK activity but not PKCa induced by angiotensin II in the brain. J Endocrinol 240:345-360 (2019). PubMed: 30508412