Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
Involvement in disease
Meckel syndrome 1 Bardet-Biedl syndrome 13
Contains 1 B9 domain.
Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Localizes at the transition zone, a region between the basal body and the ciliary axoneme.