Overview

  • Product name

    ML 141, Cdc42 GTPase inhibitor
  • Description

    Selective, cell-permeable, reversible, non-competitive Cdc42 GTPase inhibitor
  • Biological description

    Selective, cell-permeable, reversible, non-competitive Cdc42 GTPase inhibitor (IC50 = 2.6 μM). Shows antiproliferative effects. Shows anticonvulsant effects in vivo.
  • Purity

    > 98%
  • CAS Number

    71203-35-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Zhang Y  et al. Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats. Neuroscience 289:381-91 (2015). Read more (PubMed: 25595978) »
  • Ferru-Clément R  et al. Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells. PLoS One 10:e0118943 (2015). Read more (PubMed: 25768293) »
  • Chen HY  et al. Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells. EMBO Mol Med 5:723-36 (2013). Read more (PubMed: 23606532) »

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