Key features and details
- Selective TRPML agonist
- CAS Number: 332382-54-4
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameML-SA1, TRPML agonist
DescriptionSelective TRPML agonist
Selective TRPML agonist. Induces TRPML1, 2 and 3-mediated Ca2+ release from lysosomes in vitro. Does not activate TRPM2, TRPV2, TRPA1, TRPV3, TRPC6 channels. Cell-permeable.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 10 mM and in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144622 has been referenced in 1 publication.
- Wang Y et al. Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia. Oxid Med Cell Longev 2018:4612727 (2018). PubMed: 30662583