Overview

  • Product name

    ML-SA1, TRPML agonist
  • Description

    Selective TRPML agonist
  • Biological description

    Selective TRPML agonist. Induces TRPML1, 2 and 3-mediated Ca2+ release from lysosomes in vitro. Does not activate TRPM2, TRPV2, TRPA1, TRPV3, TRPC6 channels. Cell-permeable.
  • Purity

    > 98%
  • CAS Number

    332382-54-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
  • Molecular weight

    362.42
  • Molecular formula

    C22H22N2O3
  • PubChem identifier

    2880983
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C4c1ccccc1C(=O)N4CC(=O)N3c2ccccc2C(C)CC3(C)C
  • Source

    Synthetic

References

This product has been referenced in:

  • Shen D  et al. Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat Commun 3:731 (2012). Read more (PubMed: 22415822) »
  • Grimm C  et al. Role of TRPML and two-pore channels in endolysosomal cation homeostasis. J Pharmacol Exp Ther 342:236-44 (2012). Read more (PubMed: 22518024) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144622.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up