Overview

  • Product name

    ML130, NOD1 inhibitor
  • Description

    Potent, selective, cell-permeable NOD1 inhibitor
  • Biological description

    Potent, selective NOD1 inhibitor (IC50 = 560 nM). Inhibits NOD1-induced NF-κB activation in vitro. Cell-permeable.
  • Purity

    > 97%
  • CAS Number

    799264-47-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Zheng W  et al. TNFa and IL-1ß are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS. Biochem Biophys Res Commun 420:762-7 (2012). Read more (PubMed: 22450316) »
  • Correa RG  et al. Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem Biol 18:825-32 (2011). Read more (PubMed: 21802003) »
  • Khan PM  et al. Identification of Inhibitors of NOD1-Induced Nuclear Factor-?B Activation. ACS Med Chem Lett 2:780-785 (2011). Read more (PubMed: 22003428) »

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