Overview

  • Product name

    ML7, myosin light chain kinase inhibitor
  • Description

    Potent, selective myosin light chain kinase inhibitor
  • Biological description

    Potent and selective myosin light chain kinase inhibitor (MLCK) (Ki = 300 nM). Also inhibits PKA and PKC (Ki values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.
  • Purity

    > 99%
  • CAS Number

    110448-33-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Hexahydro-1-[(5-Iodo-1-naphthaleny)sulfonyl]-1H-1,4-diazepine hydrochloride
  • Molecular weight

    452.74
  • Molecular formula

    C15H17IN2O2S.HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Barkan D  et al. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res 68:6241-50 (2008). Read more (PubMed: 18676848) »
  • Petrache I  et al. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 280:L1168-78 (2001). Read more (PubMed: 11350795) »
  • Zhou FQ & Cohan CS Growth cone collapse through coincident loss of actin bundles and leading edge actin without actin depolymerization. J Cell Biol 153:1071-84 (2001). Read more (PubMed: 11381091) »
See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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