• Product name
  • Description
    Goat polyclonal to MLH3

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Host species
  • Species reactivity

    Predicted to work with: Human
  • Immunogen

    Synthetic peptide:


    , corresponding to C terminal amino acids 1416-1429 of Human MLH3.

  • General notes
    Gene Ontology terms - satellite DNA binding; ATP binding; molecular_function unknown; mismatch repair; biological_process unknown; nucleus; cellular_component unknown


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
  • Isotype
  • Research areas


  • Application notes
    Tested in peptide ELISA. Antibody detection limit dilution 1/2000.
    Western Blot: No signal obtained yet but low background observed in HeLa lysate at up to 2µg/ml.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Probably involved in the repair of mismatches in DNA.
    • Tissue specificity
    • Involvement in disease
      Defects in MLH3 are the cause of hereditary non-polyposis colorectal cancer type 7 (HNPCC7) [MIM:614385]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.
      Defects in MLH3 are a cause of colorectal cancer (CRC) [MIM:114500].
    • Sequence similarities
      Belongs to the DNA mismatch repair mutL/hexB family.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • DNA mismatch repair protein Mlh3 antibody
      • HNPCC 7 antibody
      • HNPCC antibody
      • HNPCC7 antibody
      • MGC138372 antibody
      • Mismatch repair gene MLH 3 antibody
      • Mismatch repair gene MLH3 antibody
      • MLH 3 antibody
      • MLH3 antibody
      • MLH3_HUMAN antibody
      • MutL homolog 3 (E. coli) antibody
      • MutL homolog 3 antibody
      • MutL protein homolog 3 antibody
      • S240II117 antibody
      see all


    ab4834 has not yet been referenced specifically in any publications.

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