Anti-MLKL antibody - N-terminal (ab194699)

Rabbit polyclonal MLKL antibody. Validated in WB, IHC and tested in Human. Cited in 7 publication(s). Immunogen corresponding to recombinant fragment.

Overview

  • Product name

    Anti-MLKL antibody - N-terminal
    See all MLKL primary antibodies
  • Description

    Rabbit polyclonal to MLKL - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human MLKL aa 1-53 (N terminal).
    Sequence:

    MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSV


    Database link: Q8NB16

  • Positive control

    • THP1 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab194699 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 54 kDa.
IHC-P 1/50 - 1/200.

Target

  • Sequence similarities

    Belongs to the protein kinase superfamily.
    Contains 1 protein kinase domain.
  • Domain

    The protein kinase domain is predicted to be catalytically inactive.
  • Information by UniProt
  • Database links

  • Alternative names

    • 9130019I15Rik antibody
    • FLJ34389 antibody
    • hMLKL antibody
    • Mixed lineage kinase domain like antibody
    • Mixed lineage kinase domain like protein antibody
    • Mixed lineage kinase domain like pseudokinase antibody
    • Mixed lineage kinase domain-like protein antibody
    • Mlkl antibody
    • MLKL_HUMAN antibody
    see all

Images

  • Anti-MLKL antibody - N-terminal (ab194699) at 1/500 dilution + THP-1 cell lysate

    Predicted band size: 54 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver cancer tissue sections labeling MLKL with ab194699 at 1/100 dilution.

References

This product has been referenced in:

  • Xu H  et al. The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation. Mol Metab 23:14-23 (2019). Read more (PubMed: 30837196) »
  • D'Cruz AA  et al. The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Sci Signal 11:N/A (2018). Read more (PubMed: 30181240) »
See all 9 Publications for this product

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