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ab187091 has been referenced in 50 publications.

  • Mishra SK  et al. Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells. Biochim Biophys Acta Mol Cell Biol Lipids 1864:158-167 (2019). PubMed: 30472325
  • Frank D  et al. Activated MLKL attenuates autophagy following its translocation to intracellular membranes. J Cell Sci 132:N/A (2019). PubMed: 30709919
  • Eleftheriadis T  et al. Cell Death Patterns Due to Warm Ischemia or Reperfusion in Renal Tubular Epithelial Cells Originating from Human, Mouse, or the Native Hibernator Hamster. Biology (Basel) 7:N/A (2018). PubMed: 30445750
  • Petrie EJ  et al. Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis. Nat Commun 9:2422 (2018). PubMed: 29930286
  • Ali M & Mocarski ES Proteasome inhibition blocks necroptosis by attenuating death complex aggregation. Cell Death Dis 9:346 (2018). PubMed: 29497034
  • von Mässenhausen A  et al. Phenytoin inhibits necroptosis. Cell Death Dis 9:359 (2018). PubMed: 29500402
  • Du Y  et al. Acetylcholine and necroptosis are players in follicular development in primates. Sci Rep 8:6166 (2018). PubMed: 29670172
  • Zhu K  et al. Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis 9:500 (2018). PubMed: 29703889
  • Kabashima A  et al. Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma. J Hepatol 68:1228-1238 (2018). WB . PubMed: 29408314
  • González-Juarbe N  et al. Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ 24:917-928 (2017). WB ; Human . PubMed: 28387756
  • Yang C  et al. Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis. Cell Death Dis 8:e3084 (2017). PubMed: 28981102
  • Dasari SK  et al. Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death. Cell Death Differ 24:1288-1302 (2017). WB ; Human . PubMed: 28574511
  • Tanzer MC  et al. Combination of IAP antagonist and IFN? activates novel caspase-10- and RIPK1-dependent cell death pathways. Cell Death Differ 24:481-491 (2017). PubMed: 28106882
  • Bailey LJ  et al. Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis. Cell Death Dis 8:e2590 (2017). PubMed: 28151467
  • Huang D  et al. The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process. Mol Cell Biol 37:N/A (2017). PubMed: 27920255
  • Dong W  et al. Protective effect of NSA on intestinal epithelial cells in a necroptosis model. Oncotarget 8:86726-86735 (2017). PubMed: 29156831
  • He GW  et al. Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. J Exp Med 214:1655-1662 (2017). PubMed: 28476895
  • Dong W  et al. NADPH oxidase inhibitor, diphenyleneiodonium prevents necroptosis in HK-2 cells. Biomed Rep 7:226-230 (2017). PubMed: 28894570
  • Szobi A  et al. Analysis of necroptotic proteins in failing human hearts. J Transl Med 15:86 (2017). WB ; Human . PubMed: 28454582
  • Zargarian S  et al. Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis. PLoS Biol 15:e2002711 (2017). WB ; Human . PubMed: 28650960
  • Zhou X  et al. The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis. Cell Death Discov 3:17027 (2017). IF ; Human . PubMed: 28660075
  • Gong YN  et al. ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences. Cell 169:286-300.e16 (2017). PubMed: 28388412
  • Yoon S  et al. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity 47:51-65.e7 (2017). PubMed: 28666573
  • Gong YN  et al. Biological events and molecular signaling following MLKL activation during necroptosis. Cell Cycle 16:1748-1760 (2017). PubMed: 28854080
  • Gaidt MM  et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell 171:1110-1124.e18 (2017). PubMed: 29033128
  • Ma W  et al. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNFa-Mediated Antiproliferative Effects and Necroptosis. Front Immunol 7:496 (2016). WB . PubMed: 27920775
  • Rodriguez DA  et al. Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis. Cell Death Differ 23:76-88 (2016). PubMed: 26024392
  • Ma B  et al. ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis. PLoS One 11:e0165983 (2016). Human . PubMed: 27832137
  • Anderson C  et al. E-Cigarette Aerosol Exposure Induces Reactive Oxygen Species, DNA Damage, and Cell Death in Vascular Endothelial Cells. Toxicol Sci N/A:N/A (2016). PubMed: 27613717
  • Wang X  et al. Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming. J Immunol 197:4090-4100 (2016). PubMed: 27815445
  • Quarato G  et al. Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis. Mol Cell N/A:N/A (2016). WB ; Mouse . PubMed: 26853145
  • Zhao XM  et al. Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis. Cell Death Dis 7:e2089 (2016). WB ; Human . PubMed: 26866270
  • Gautheron J  et al. The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance. Nat Commun 7:11869 (2016). WB ; Mouse . PubMed: 27323669
  • Cai Z  et al. Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration. Cell Res N/A:N/A (2016). WB ; Human . PubMed: 27444869
  • Strilic B  et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature 536:215-8 (2016). PubMed: 27487218
  • Al-Lamki RS  et al. Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis. Cell Death Dis 7:e2287 (2016). PubMed: 27362805
  • Li D  et al. Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis. Cell Chem Biol 23:257-266 (2016). PubMed: 27028885
  • Yoon S  et al. Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ 23:253-60 (2016). WB, ICC . PubMed: 26184911
  • Afonso MB  et al. Activation of necroptosis in human and experimental cholestasis. Cell Death Dis 7:e2390 (2016). PubMed: 27685634
  • Li D  et al. A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc Natl Acad Sci U S A 112:5017-22 (2015). PubMed: 25852146
  • Delaney JR  et al. A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. Oncotarget 6:31104-18 (2015). PubMed: 26418751
  • Fauster A  et al. A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis 6:e1767 (2015). PubMed: 25996294
  • Omoto S  et al. Suppression of RIP3-dependent necroptosis by human cytomegalovirus. J Biol Chem 290:11635-48 (2015). PubMed: 25778401
  • Philipp S  et al. Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis. Cell Commun Signal 13:25 (2015). WB . PubMed: 25925126
  • Guo H  et al. Herpes simplex virus suppresses necroptosis in human cells. Cell Host Microbe 17:243-51 (2015). PubMed: 25674983
  • Ratovitski EA Phospho-?Np63a-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure. FEBS Lett 589:1352-8 (2015). PubMed: 25910754
  • Wang H  et al. Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3. Mol Cell N/A:N/A (2014). PubMed: 24703947
  • Ji W  et al. Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death. PLoS One 9:e103224 (2014). Human . PubMed: 25068797
  • McCabe KE  et al. Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma. Cell Death Dis 5:e1496 (2014). PubMed: 25356865
  • Sun L  et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148:213-27 (2012). PubMed: 22265413

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