MLN-4924, NEDD8-activating enzyme inhibitor (ab216470)

Overview

  • Product name

    MLN-4924, NEDD8-activating enzyme inhibitor
  • Description

    Potent, selective NEDD8-activating enzyme inhibitor
  • Alternative names

    • MLN 4924
    • MLN4924
    • Pevonedistat
  • Purity

    > 98%
  • CAS Number

    905579-51-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    ((1S,2S,4R)-4-(4-(((S)-2,3-Dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate
  • Molecular weight

    443.53
  • Molecular formula

    C21H25N5O4S
  • PubChem identifier

    16720766
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 20 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Lan H  et al. Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells. Sci Rep 6:24218 (2016). Read more (PubMed: 27063292) »
  • Milhollen MA  et al. MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. Blood 116:1515-23 (2010). Read more (PubMed: 20525923) »
  • Soucy TA  et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458:732-6 (2009). Read more (PubMed: 19360080) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab216470.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up