MLN2480, pan-Raf kinase inhibitor (ab235508)

Overview

  • Product name

    MLN2480, pan-Raf kinase inhibitor
  • Description

    Selective pan-Raf kinase inhibitor.
  • Alternative names

    • AMG 2112819
    • BIIB 024
    • BIIB024
    • ML N2480
    • TAK 58
    • TAK 580
    • TAK580
    see all
  • Purity

    > 98%
  • General notes

    Protect from air and light.

    Soluble in DMSO.

  • CAS Number

    1096708-71-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide
  • Molecular weight

    506.29
  • Molecular formula

    C17H12Cl2F3N7O2S
  • PubChem identifier

    25161177
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C1=NC=C(S1)C(=O)NC2=NC=C(C(=C2)C(F)(F)F)Cl)NC(=O)C3=C(C(=NC=N3)N)Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Sun Y  et al. A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas. Neuro Oncol 19:774-785 (2017). Read more (PubMed: 28082416) »
  • Whittaker SR  et al. Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors. Mol Cancer Ther 14:2700-11 (2015). Read more (PubMed: 26351322) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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