• Product name
  • Description
    Rabbit polyclonal to MLN51/CASC3
  • Host species
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Opossum, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 653-703 of Human MLN51/CASC3 (NP_031385.2).

  • Positive control
    • Human Breast Carcinoma tissue.



Our Abpromise guarantee covers the use of ab118803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


  • Function
    Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favouring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons (By similarity). May play a role in mRNA transport (By similarity). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.
  • Tissue specificity
    Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers.
  • Sequence similarities
    Belongs to the CASC3 family.
  • Domain
    The coiled coil domain may be involved in oligomerization.
  • Post-translational
    ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
    Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation.
  • Cellular localization
    Cytoplasm > perinuclear region. Nucleus. Nucleus speckle. Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress.
  • Information by UniProt
  • Database links
  • Alternative names
    • Barentsz antibody
    • Barentsz protein antibody
    • Btz antibody
    • Cancer susceptibility candidate 3 antibody
    • Cancer susceptibility candidate gene 3 protein antibody
    • CASC3 antibody
    • CASC3_HUMAN antibody
    • Metastatic lymph node 51 antibody
    • Metastatic lymph node gene 51 protein antibody
    • Metastatic lymph node protein 51 antibody
    • MLN 51 antibody
    • MLN 51 protein antibody
    • MLN51 antibody
    • Protein barentsz antibody
    • Protein CASC3 antibody
    • Protein MLN 51 antibody
    see all


  • ab118803, at 1/250 dilution, staining MLN51/CASC3 in formalin-fixed, paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry with DAB staining.


This product has been referenced in:
  • Bhuvanagiri M  et al. 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion. EMBO Mol Med 6:1593-609 (2014). WB ; Human . Read more (PubMed: 25319547) »

See 1 Publication for this product

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