Overview

  • Product name

    MM 11253, RARgamma
  • Description

    Selective RARγ antagonist
  • Biological description

    Selective RARγ antagonist. Blocks the growth inhibitory effects of RARγ-selective agonists. Shows antiapoptotic effects.
  • Purity

    > 98%
  • CAS Number

    345952-44-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthanenecarboxylic acid
  • Molecular weight

    462.66
  • Molecular formula

    C28H30O2S2
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)c1ccc2cc(ccc2c1)C3(SCCS3)c4ccc5c(c4)C(C)(C)CCC5(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Dawson MI  et al. Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Res 61:4723-30 (2001). Read more (PubMed: 11406543) »
  • Le Q  et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene 19:1457-65 (2000). Read more (PubMed: 10723137) »
  • Holmes WF  et al. Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J Cell Physiol 185:61-7 (2000). Read more (PubMed: 10942519) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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