Overview

  • Product name

    Anti-MMAA antibody
  • Description

    Rabbit polyclonal to MMAA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 96-145 (GQRACLAEAI TLVESTHSRK KELAQVLLQK VLLYHREQEQ SNKGKPLAFR) of Human MMAA (NP_758454).

  • Positive control

    • RPMI-8226 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab130964 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 47 kDa.

Target

  • Function

    Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis.
  • Tissue specificity

    Widely expressed. Highest expression is observed in liver and skeletal muscle.
  • Pathway

    Cofactor biosynthesis; adenosylcobalamin biosynthesis.
  • Involvement in disease

    Defects in MMAA are the cause of methylmalonic aciduria type cblA (MMAA) [MIM:251100]; also known as methylmalonic aciduria type A or vitamin B12-responsive methylmalonicaciduria of cblA complementation type. MMAA is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.
  • Sequence similarities

    Belongs to the ArgK family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • cblA antibody
    • Methylmalonic aciduria (cobalamin deficiency) cblA type antibody
    • Methylmalonic aciduria (cobalamin deficiency) type A antibody
    • Methylmalonic aciduria type A protein antibody
    • Methylmalonic aciduria type A protein mitochondrial antibody
    • MGC120010 antibody
    • MGC120011 antibody
    • MGC120012 antibody
    • MGC120013 antibody
    • mitochondrial antibody
    • MMAA antibody
    • MMAA_HUMAN antibody
    • OTTHUMP00000220105 antibody
    see all

Images

  • Anti-MMAA antibody (ab130964) at 1 µg/ml + RPMI-8226 cell lysate at 10 µg

    Secondary
    Goat anti-Rabbit IgG HRP

    Predicted band size: 47 kDa



    Gel concentration: 12%.

References

ab130964 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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