• Product name

  • Description

    Rabbit polyclonal to MMACHC/CblC
  • Host species

  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment corresponding to Human MMACHC/CblC aa 1-188.
    Database link: NP_056321

  • Positive control

    • 293T and Raji whole cell lysates; HeLa cells; A431, H1299, HeLaS3 and HepG2 cell lines
  • General notes

     This product was previously labelled as MMACHC




Our Abpromise guarantee covers the use of ab96195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 32 kDa.
ICC/IF 1/100 - 1/200.


  • Function

    May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
  • Tissue specificity

    Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes.
  • Pathway

    Cofactor biosynthesis; adenosylcobalamin biosynthesis.
  • Involvement in disease

    Defects in MMACHC are the cause of methylmalonic aciduria and homocystinuria type cblC (MMACHC) [MIM:277400]. MMACHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). Affected individuals may have developmental, hematologic, neurologic, metabolic, ophthalmologic, and dermatologic clinical findings. Although considered a disease of infancy or childhood, some individuals develop symptoms in adulthood.
  • Sequence similarities

    Belongs to the MMACHC family.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1810037K07Rik antibody
    • BOS_3654 antibody
    • cblC antibody
    • DKFZp564I122 antibody
    • FLJ25671 antibody
    • Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria antibody
    • Methylmalonic aciduria and homocystinuria type C protein antibody
    • Methylmalonic aciduria and homocystinuria type C protein homolog antibody
    • MGC134307 antibody
    • MMAC_HUMAN antibody
    • MMACHC antibody
    • OTTHUMP00000009243 antibody
    • RP11 291L19.3 antibody
    • RP23-177C18.3 antibody
    see all


  • All lanes : Anti-MMACHC/CblC antibody (ab96195) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 32 kDa

    12% SDS-PAGE
  • ab96195, at 1/100 dilution, staining MMACHC/CblC in paraformaldehyde-fixed HeLa cells by Immunofluorescence. Lower image is merged with DNA probe.


This product has been referenced in:

  • Fofou-Caillierez MB  et al. Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia. Hum Mol Genet N/A:N/A (2013). Read more (PubMed: 23825108) »
  • Yu HC  et al. An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1. Am J Hum Genet 93:506-14 (2013). Read more (PubMed: 24011988) »
See all 2 Publications for this product

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