Overview

  • Product name
    MMK1, FPR2 agonist
  • Description
    Potent, selective FPR2 agonist
  • Biological description
    Potent, selective human formyl peptide receptor FPR2 agonist (EC50 = 1, 2 and > 10 000 nM for mFRP2, hFPR2 and hFPR1 respectively). Induces chemotaxis of human monocytes and neutrophils. Enhances production of IL-1β and IL-6. Activates NADPH-oxidase.
  • Purity
    > 98%
  • CAS Number
    271246-66-3
  • Chemical structure
    Chemical Structure

Properties

  • Molecular weight
    1611.00
  • Molecular formula
    C75H123N19O18S
  • Sequence
    LESIFRSLLFRVM
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    [H]/N=C(\N)/NCCC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN/C(=N/[H])/N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Karlsson J  et al. The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium channels. Cell Calcium 45:431-8 (2009). Read more (PubMed: 19282028) »
  • Nanamori M  et al. A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol Pharmacol 66:1213-22 (2004). Read more (PubMed: 15308762) »
  • Hu JY  et al. Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. J Leukoc Biol 70:155-61 (2001). Read more (PubMed: 11435499) »

Customer reviews and Q&As

Answer


I can confirm that this compound has not been tested by us in a murine system.
But I found some publications that have used MMK1 with the mouse equivalent of FPR2:
http://www.ncbi.nlm.nih.gov/pubmed/11435499
http://www.jbc.org/content/288/23/16262.full
These publications indicate that the MMK1 peptide can also be used in a murine system.

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"
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