MMP-2/MMP-9 Inhibitor I, MMP-2/MMP-9 inhibitor (ab145190)

Overview

  • Product name
    MMP-2/MMP-9 Inhibitor I, MMP-2/MMP-9 inhibitor
  • Description
    MMP-2/MMP-9 inhibitor
  • Alternative names
    • Compound 5a
  • Biological description
    Matrix metalloproteinase inhibitor of MMP-2/MMP-9. Synergizes with TNF-α to induce apoptosis in cancer cells. Active in vitro.
  • Purity
    > 99%
  • CAS Number
    193807-58-8
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    N-[(1,1'-Biphenyl)-4-ylsulfonyl]-D-phenylalanine
  • Molecular weight
    381.45
  • Molecular formula
    C21H19NO4S
  • PubChem identifier
    10667540
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C(C=C1)CC(C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3
  • Source

    Synthetic

References

This product has been referenced in:
  • O'Grady A  et al. Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression. Histopathology 51:793-804 (2007). Read more (PubMed: 18042068) »
  • Nyormoi O  et al. An MMP-2/MMP-9 inhibitor, 5a, enhances apoptosis induced by ligands of the TNF receptor superfamily in cancer cells. Cell Death Differ 10:558-69 (2003). Read more (PubMed: 12728254) »
  • Tamura Y  et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J Med Chem 41:640-9 (1998). Read more (PubMed: 9484512) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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