Overview

  • Product name

    Anti-MMP11 antibody - C-terminal
    See all MMP11 primary antibodies
  • Description

    Rabbit polyclonal to MMP11 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Mouse MMP11 (C terminal). Surrounding amino acid 464
    Database link: Q02853

  • Positive control

    • Human adrenal tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab189214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 55 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    May play an important role in the progression of epithelial malignancies.
  • Tissue specificity

    Specifically expressed in stromal cells of breast carcinomas.
  • Sequence similarities

    Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • Domain

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications

    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • Matrix Metalloproteinase 11 antibody
    • Matrix metalloproteinase-11 antibody
    • MMP-11 antibody
    • Mmp11 antibody
    • MMP11_HUMAN antibody
    • SL 3 antibody
    • SL-3 antibody
    • SL3 antibody
    • ST3 antibody
    • STMY3 antibody
    • Stromelysin 3 antibody
    • Stromelysin III antibody
    • Stromelysin-3 antibody
    see all

Images

  • Immunohistochemistry of formalin-fixed, paraffin-embedded Human adrenal tissue labelling MMP11 with ab188214 at 5 µg/ml.

References

ab189214 has not yet been referenced specifically in any publications.

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