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ab39012 has been referenced in 107 publications.

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  • Mu W  et al. Halofuginone Attenuates Osteoarthritis by Rescuing Bone Remodeling in Subchondral Bone Through Oral Gavage. Front Pharmacol 9:269 (2018). PubMed: 29636687
  • Wang W  et al. Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration. Int J Mol Med 41:2553-2564 (2018). PubMed: 29436582
  • Lin H  et al. Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFß-dependent manner and limits osteoarthritis in mice. Sci Rep 8:10488 (2018). PubMed: 29992982
  • Ma CT  et al. Fusobacterium nucleatum promotes the progression of colorectal cancer by interacting with E-cadherin. Oncol Lett 16:2606-2612 (2018). PubMed: 30013655
  • Yang Y  et al. Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-?B Pathway. Front Pharmacol 9:598 (2018). PubMed: 29928231
  • Chen Y  et al. Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model. Int J Biol Sci 14:682-692 (2018). PubMed: 29904282
  • Zhang C  et al. Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice. Osteoarthritis Cartilage 26:824-833 (2018). IHC ; Mouse . PubMed: 29549054
  • Zuo C  et al. SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity. Bone Res 6:12 (2018). PubMed: 29644115
  • Han S  et al. Dicam promotes proliferation and maturation of chondrocyte through Indian hedgehog signaling in primary cilia. Osteoarthritis Cartilage 26:945-953 (2018). ICC/IF . PubMed: 29702220
  • Hui T  et al. Activation of ß-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects. Int J Oral Sci 10:13 (2018). IHC-P ; Mouse . PubMed: 29686224
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  • Sun W  et al. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Exp Ther Med 15:1119-1128 (2018). PubMed: 29434702
  • Wang G  et al. Lycorine Suppresses Endplate-Chondrocyte Degeneration and Prevents Intervertebral Disc Degeneration by Inhibiting NF-?B Signalling Pathway. Cell Physiol Biochem 45:1252-1269 (2018). PubMed: 29448253
  • Kang X  et al. Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK-eIF-2a-CHOP pathway in the unfolded protein response. J Biol Chem 293:8614-8625 (2018). PubMed: 29653943
  • Monteagudo S  et al. DOT1L safeguards cartilage homeostasis and protects against osteoarthritis. Nat Commun 8:15889 (2017). PubMed: 28627522
  • Jeon OH  et al. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med 23:775-781 (2017). IHC-P ; Mouse . PubMed: 28436958
  • Li Y  et al. MMP-2 and MMP-13 affect vasculogenic mimicry formation in large cell lung cancer. J Cell Mol Med 21:3741-3751 (2017). PubMed: 28766880
  • Matsuzaki T  et al. Transthyretin deposition promotes progression of osteoarthritis. Aging Cell 16:1313-1322 (2017). WB, IHC-P . PubMed: 28941045
  • Dole NS  et al. Osteocyte-Intrinsic TGF-ß Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling. Cell Rep 21:2585-2596 (2017). IHC-P ; Mouse . PubMed: 29186693
  • Liu Z  et al. Hypoxia-inducible factor-la mediates aggrecan and collagen ? expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration. Biochem Biophys Res Commun 488:554-561 (2017). WB . PubMed: 28526405
  • Zhang X  et al. miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2. Cell Death Dis 8:e2734 (2017). PubMed: 28383548
  • Rath N  et al. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Mol Med 9:198-218 (2017). PubMed: 28031255
  • John AMSP  et al. GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney. Sci Rep 7:10924 (2017). PubMed: 28883608
  • Liu S  et al. Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/ß-catenin signaling pathways. Exp Ther Med 14:5057-5062 (2017). PubMed: 29201214
  • Makino H  et al. A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain. Sci Rep 7:16983 (2017). PubMed: 29208967
  • Hao XD  et al. De novo mutations of TUBA3D are associated with keratoconus. Sci Rep 7:13570 (2017). PubMed: 29051577
  • Nagao M  et al. Vascular Endothelial Growth Factor in Cartilage Development and Osteoarthritis. Sci Rep 7:13027 (2017). PubMed: 29026147
  • Jeong JW  et al. Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate-induced osteoarthritis rats. Mol Med Rep 16:3841-3848 (2017). PubMed: 29067461
  • Wang J  et al. Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1ß is mediated by curcumin via inhibition of NF-?B signaling in rat chondrocytes. Mol Med Rep 16:1837-1845 (2017). PubMed: 28627596
  • Song B  et al. Beclin 1 overexpression inhibits chondrocyte apoptosis and downregulates extracellular matrix metabolism in osteoarthritis. Mol Med Rep 16:3958-3964 (2017). PubMed: 28731147
  • Lian C  et al. Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells. Mol Med Rep 16:4730-4736 (2017). PubMed: 28791354
  • Ji B  et al. Isoliquiritigenin suppresses IL-1ß induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-?B and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection. Int J Mol Med 40:1709-1718 (2017). PubMed: 29039445
  • Yang G  et al. Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1ß-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-?B Pathway. Biomed Res Int 2017:8686207 (2017). PubMed: 29333456
  • Shaheen NL  et al. Extracellular matrix composition modulates angiosarcoma cell attachment and proliferation. Oncoscience 4:178-188 (2017). PubMed: 29344556
  • McKay TB  et al. Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro. PLoS One 12:e0176017 (2017). WB ; Human . PubMed: 28426715
  • Hu J  et al. BMSC paracrine activity attenuates interleukin-1ß-induced inflammation and apoptosis in rat AF cells via inhibiting relative NF-?B signaling and the mitochondrial pathway. Am J Transl Res 9:79-89 (2017). WB ; Rat . PubMed: 28123635
  • Corciulo C  et al. Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression. Nat Commun 8:15019 (2017). Mouse, Rat . PubMed: 28492224
  • Carpio LR  et al. Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes. Connect Tissue Res 58:27-36 (2017). PubMed: 27662443
  • Chen NM  et al. Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity. Gastroenterology 152:1507-1520.e15 (2017). PubMed: 28188746
  • Wu J  et al. Wnt-ß-catenin signaling pathway inhibition by sclerostin may protect against degradation in healthy but not osteoarthritic cartilage. Mol Med Rep 15:2423-2432 (2017). PubMed: 28259981
  • Pajak A  et al. Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis. J Pain Res 10:1973-1989 (2017). PubMed: 28860852
  • Deng Y  et al. Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair. Cell Rep 14:2224-2237 (2016). PubMed: 26923596
  • Todorov A  et al. Fat-Derived Stromal Vascular Fraction Cells Enhance the Bone-Forming Capacity of Devitalized Engineered Hypertrophic Cartilage Matrix. Stem Cells Transl Med 5:1684-1694 (2016). PubMed: 27460849
  • Schüler-Toprak S  et al. Agonists and knockdown of estrogen receptor ß differentially affect invasion of triple-negative breast cancer cells in vitro. BMC Cancer 16:951 (2016). PubMed: 28003019
  • Koskinen-Kolasa A  et al. Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3. Arthritis Res Ther 18:215 (2016). PubMed: 27716333
  • Carpio LR  et al. Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling. Sci Signal 9:ra79 (2016). IHC-P ; Mouse . PubMed: 27507649
  • Wu X  et al. The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration. Sci Rep 6:30563 (2016). PubMed: 27460424
  • Yan B  et al. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun 7:11151 (2016). PubMed: 27039827
  • Liang Y  et al. E2 regulates MMP-13 via targeting miR-140 in IL-1ß-induced extracellular matrix degradation in human chondrocytes. Arthritis Res Ther 18:105 (2016). WB . PubMed: 27165343
  • Nakamura A  et al. Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration. JCI Insight 1:e86820 (2016). PubMed: 27699225
  • Hirahata M  et al. PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma. Cancer Med 5:892-902 (2016). WB . PubMed: 26817521
  • Arun MZ  et al. Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress. Drug Des Devel Ther 10:1453-60 (2016). WB . PubMed: 27143852
  • Fu J  et al. Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease. J Clin Invest 126:1759-72 (2016). PubMed: 27043283
  • Yang W  et al. Clock gene Bmal1 modulates human cartilage gene expression by crosstalk with Sirt1. Endocrinology N/A:en20152042 (2016). WB ; Human . PubMed: 27253997
  • Sun Y  et al. Effect of pERK2 on extracellular matrix turnover of the fibrotic joint capsule in a post-traumatic joint contracture model. Exp Ther Med 11:547-552 (2016). IHC-Fr ; Rat . PubMed: 26893645
  • Wang C  et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep 6:34330 (2016). WB ; Human . PubMed: 27680712
  • Osinga R  et al. Generation of a Bone Organ by Human Adipose-Derived Stromal Cells Through Endochondral Ossification. Stem Cells Transl Med 5:1090-7 (2016). PubMed: 27334490
  • Papathanasiou I  et al. Molecular changes indicative of cartilage degeneration and osteoarthritis development in patients with anterior cruciate ligament injury. BMC Musculoskelet Disord 17:21 (2016). WB ; Human . PubMed: 26762166
  • Chen L  et al. Lentiviral-mediated overexpression of long non-coding RNA GAS5 reduces invasion by mediating MMP2 expression and activity in human melanoma cells. Int J Oncol 48:1509-18 (2016). PubMed: 26846479
  • Zhang ZM  et al. Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2-STAT3 signaling pathway. Mol Med Rep 13:3684-90 (2016). PubMed: 26936086
  • Cherepanova OA  et al. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med 22:657-65 (2016). PubMed: 27183216
  • Grootaert MOJ  et al. NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice. Atherosclerosis 252:166-174 (2016). PubMed: 27425215
  • Hu H  et al. Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-?B pathways in the cartilage tissue of rats with osteoarthritis. Int J Mol Med 38:1922-1932 (2016). PubMed: 27748894
  • Zhu S  et al. Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development. Arthritis Rheumatol 67:2154-63 (2015). PubMed: 25917196
  • Mendonsa AM  et al. Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver. Mol Cancer 14:49 (2015). WB . PubMed: 25880591
  • Saigusa R  et al. Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis. Proc Natl Acad Sci U S A 112:15136-41 (2015). WB, IHC-P ; Mouse . PubMed: 26598674
  • Tang J  et al. Effects of mesenchymal stem cells on interleukin-1ß-treated chondrocytes and cartilage in a rat osteoarthritic model. Mol Med Rep 12:1753-60 (2015). WB ; Rat . PubMed: 25892273
  • Shen P  et al. Injecting vascular endothelial growth factor into the temporomandibular joint induces osteoarthritis in mice. Sci Rep 5:16244 (2015). IHC . PubMed: 26531672
  • Kim YH & Kang JS Effect of methotrexate on collagen-induced arthritis assessed by micro-computed tomography and histopathological examination in female rats. Biomol Ther (Seoul) 23:195-200 (2015). IHC . PubMed: 25767689
  • Meyer MB  et al. Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions. J Biol Chem 290:11093-107 (2015). PubMed: 25773540
  • Wang Z  et al. Interleukin-2 is upregulated in patients with a prolapsed lumbar intervertebral disc and modulates cell proliferation, apoptosis and extracellular matrix metabolism of human nucleus pulposus cells. Exp Ther Med 10:2437-2443 (2015). WB ; Human . PubMed: 26668654
  • Yoshida M  et al. The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun 6:6653 (2015). PubMed: 25808752
  • Gronnier C  et al. The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells. Biochim Biophys Acta 1843:2432-7 (2014). PubMed: 25003315
  • Hayes EM  et al. Classical and Alternative Activation and Metalloproteinase Expression Occurs in Foam Cell Macrophages in Male and Female ApoE Null Mice in the Absence of T and B Lymphocytes. Front Immunol 5:537 (2014). IHC-P ; Mouse . PubMed: 25389425
  • Moon HJ  et al. Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration. Osteoarthritis Cartilage 22:344-54 (2014). WB ; Human . PubMed: 24361793
  • Ushijima T  et al. CCAAT/enhancer-binding protein ß regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes. J Biol Chem 289:2852-63 (2014). IHC-P ; Mouse . PubMed: 24344131
  • Akil O  et al. Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One 9:e94989 (2014). IHC-P ; Mouse . PubMed: 24788917
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  • Hettrich CM  et al. The effect of immobilization on the native and repaired tendon-to-bone interface. J Bone Joint Surg Am 95:925-30 (2013). PubMed: 23677360
  • Smith MM  et al. A hexadecylamide - derivative of hyaluronan (HYMOVIS(R)) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. J Inflamm (Lond) 10:26 (2013). WB . PubMed: 23889808
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  • Doehn U  et al. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Mol Cell 35:511-22 (2009). WB ; Dog . PubMed: 19716794
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