Recombinant
RabMAb

Anti-MMP14 antibody [EP1264Y] (ab51074)

Rabbit recombinant monoclonal MMP14 antibody [EP1264Y]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 74 publication(s). Independently reviewed in 13 review(s).

Publishing research using ab51074? Please let us know so that we can cite the reference in this datasheet.

ab51074 has been referenced in 76 publications.

  • Cui G  et al. MMP14 predicts a poor prognosis in patients with colorectal cancer. Hum Pathol 83:36-42 (2019). PubMed: 30120968
  • Fu X  et al. MT1-MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching-inhibited invasion of bone-marrow-derived mesenchymal stem cells. J Cell Physiol N/A:N/A (2019). PubMed: 30659604
  • Bennink LL  et al. Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging. Biomaterials 183:67-76 (2018). PubMed: 30149231
  • Levin G  et al. Spatio-temporal expression profile of matrix metalloproteinase (Mmp) modulators Reck and Sparc during the rat ovarian dynamics. Reprod Biol Endocrinol 16:116 (2018). PubMed: 30424792
  • Hillebrand LE  et al. MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions. FASEB J N/A:fj201801127R (2018). PubMed: 30521382
  • Di D  et al. Association of BCSC-1 and MMP-14 with human breast cancer. Oncol Lett 15:5020-5026 (2018). PubMed: 29552138
  • Li T  et al. The interactome and spatial redistribution feature of Ca2+receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion. Cell Death Dis 9:292 (2018). PubMed: 29463791
  • Braun A  et al. A cell surface display fluorescent biosensor for measuring MMP14 activity in real-time. Sci Rep 8:5916 (2018). PubMed: 29651043
  • Pekkonen P  et al. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and ß1-integrin activation. Elife 7:N/A (2018). ICC/IF ; Human . PubMed: 29712618
  • Abu El-Asrar AM  et al. Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy. Mol Vis 24:394-406 (2018). PubMed: 29853773
  • Hoffmann C  et al. Hypoxia promotes breast cancer cell invasion through HIF-1a-mediated up-regulation of the invadopodial actin bundling protein CSRP2. Sci Rep 8:10191 (2018). WB ; Human . PubMed: 29976963
  • Xiong J  et al. Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss. Nat Commun 9:2909 (2018). PubMed: 30046091
  • Cunha C  et al. Joint analysis of IVD herniation and degeneration by rat caudal needle puncture model. J Orthop Res 35:258-268 (2017). IHC ; Rat . PubMed: 26610284
  • Peláez R  et al. ß3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells. PLoS One 12:e0181579 (2017). PubMed: 28767724
  • Dourado KMC  et al. Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models. Blood 129:2526-2536 (2017). PubMed: 28351936
  • Swayampakula M  et al. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Oncogene 36:6244-6261 (2017). ICC/IF ; Human . PubMed: 28692057
  • Meehan J  et al. Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells. Oncotarget 8:42857-42875 (2017). PubMed: 28476026
  • Ding P  et al. CD147 functions as the signaling receptor for extracellular divalent copper in hepatocellular carcinoma cells. Oncotarget 8:51151-51163 (2017). PubMed: 28881637
  • Hebbrecht T  et al. VCA nanobodies target N-WASp to reduce invadopodium formation and functioning. PLoS One 12:e0185076 (2017). PubMed: 28938008
  • Landolt L  et al. Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis. Physiol Rep 5:N/A (2017). IHC . PubMed: 28596300
  • Yamamoto K  et al. Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis. Arthritis Rheumatol 69:1246-1256 (2017). PubMed: 28235248
  • Yu W  et al. Effects of autophagy and endocytosis on the activity of matrix metalloproteinase-2 in human renal proximal tubular cells under hypoxia. Mol Med Rep 15:3225-3230 (2017). PubMed: 28339082
  • Wang C  et al. Dickkopf-Related Protein 2 is Epigenetically Inactivated and Suppresses Colorectal Cancer Growth and Tumor Metastasis by Antagonizing Wnt/ß-Catenin Signaling. Cell Physiol Biochem 41:1709-1724 (2017). PubMed: 28365691
  • Bendris N  et al. Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells. J Cell Sci 129:2804-16 (2016). PubMed: 27278018
  • Petropoulos C  et al. Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes. J Cell Biol 213:585-99 (2016). PubMed: 27269065
  • Norden PR  et al. Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1. PLoS One 11:e0147758 (2016). PubMed: 26812085
  • Bogachek MV  et al. Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. Stem Cell Reports 7:1140-1151 (2016). PubMed: 27916539
  • Chen S  et al. KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP. Oncol Rep 35:971-7 (2016). PubMed: 26576027
  • Chen HZ  et al. Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. Circ Res 119:1076-1088 (2016). PubMed: 27650558
  • Zhao W  et al. Effect of TGF-ß1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14. Sci Rep 6:21176 (2016). WB, IHC-P ; Rat . PubMed: 26880204
  • Du HT & Liu P Matrix metalloproteinase 14 participates in corneal lymphangiogenesis through the VEGF-C/VEGFR-3 signaling pathway. Exp Ther Med 12:2120-2128 (2016). WB ; Mouse . PubMed: 27698700
  • Piccinini AM  et al. Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages. Sci Signal 9:ra86 (2016). ICC/IF . PubMed: 27577261
  • Daubon T  et al. VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells. J Cell Sci 129:2586-98 (2016). WB ; Human . PubMed: 27231093
  • Wong HL  et al. MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nat Commun 7:10824 (2016). PubMed: 26926389
  • Cepeda MA  et al. Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells. Mol Cancer 15:65 (2016). WB ; Human . PubMed: 27756325
  • Gallardo-Vara E  et al. Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. Angiogenesis 19:155-71 (2016). IHC, Flow Cyt . PubMed: 26850053
  • Maacha S  et al. Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14). Invest Ophthalmol Vis Sci 57:1982-90 (2016). PubMed: 27096756
  • Rafii S  et al. Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Nat Cell Biol 17:123-136 (2015). PubMed: 25621952
  • Bais MV  et al. Orthotopic non-metastatic and metastatic oral cancer mouse models. Oral Oncol 51:476-82 (2015). PubMed: 25682387
  • Ding BS  et al. Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J Cell Sci 128:2983-8 (2015). WB ; Human . PubMed: 26116571
  • Ponceau A  et al. aII-spectrin regulates invadosome stability and extracellular matrix degradation. PLoS One 10:e0120781 (2015). PubMed: 25830635
  • El Khassawna T  et al. Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats. Histochem Cell Biol 144:491-507 (2015). PubMed: 26210855
  • Kotula E  et al. DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion. Cell Cycle 14:1961-72 (2015). WB . PubMed: 26017556
  • Ager EI  et al. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. J Natl Cancer Inst 107:N/A (2015). PubMed: 25710962
  • Vincent ZL  et al. Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta. J Inflamm Res 8:193-200 (2015). WB . PubMed: 26491367
  • Shitomi Y  et al. ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1). Mol Biol Cell 26:659-73 (2015). PubMed: 25540428
  • Lu ZX  et al. Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection. BMC Cardiovasc Disord 14:53 (2014). WB, IHC . PubMed: 24742302
  • Hayes EM  et al. Classical and Alternative Activation and Metalloproteinase Expression Occurs in Foam Cell Macrophages in Male and Female ApoE Null Mice in the Absence of T and B Lymphocytes. Front Immunol 5:537 (2014). IHC-P ; Mouse . PubMed: 25389425
  • Cyr AR  et al. TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis. Oncogene N/A:N/A (2014). Human . PubMed: 24469049
  • Welch-Reardon KM  et al. Angiogenic sprouting is regulated by endothelial cell expression of Slug. J Cell Sci 127:2017-28 (2014). PubMed: 24554431
  • Hong IK  et al. The Tetraspanin CD81 Protein Increases Melanoma Cell Motility by Up-regulating Metalloproteinase MT1-MMP Expression through the Pro-oncogenic Akt-dependent Sp1 Activation Signaling Pathways. J Biol Chem 289:15691-15704 (2014). Human . PubMed: 24733393
  • Appel S  et al. CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells. PLoS One 9:e103216 (2014). WB . PubMed: 25050546
  • von Nandelstadh P  et al. Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton. Mol Biol Cell 25:2556-70 (2014). Mouse . PubMed: 24989798
  • Küttner V  et al. Global remodelling of cellular microenvironment due to loss of collagen VII. Mol Syst Biol 9:657 (2013). PubMed: 23591773
  • Kumar S  et al. Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-ß signaling. Oncogene N/A:N/A (2013). PubMed: 24077288
  • Lee JH  et al. N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells. Biochem Biophys Res Commun 431:658-63 (2013). PubMed: 23357422
  • Mori H  et al. Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin ß1. Development 140:343-52 (2013). WB . PubMed: 23250208
  • Havre PA  et al. CD26 Expression on T-Anaplastic Large Cell Lymphoma (ALCL) Line Karpas 299 is associated with increased expression of Versican and MT1-MMP and enhanced adhesion. BMC Cancer 13:517 (2013). Flow Cyt ; Human . PubMed: 24180670
  • Woskowicz AM  et al. MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion. J Biol Chem 288:35126-37 (2013). WB . PubMed: 24165131
  • Xiao Q  et al. Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions. Circ Res 112:35-47 (2013). PubMed: 23071158
  • Xiao W  et al. Knockdown of FAK inhibits the invasion and metastasis of Tca-8113 cells in vitro. Mol Med Rep 8:703-7 (2013). PubMed: 23807215
  • Urso ML  et al. Adenosine A3 receptor stimulation reduces muscle injury following physical trauma and is associated with alterations in the MMP/TIMP response. J Appl Physiol 112:658-70 (2012). WB ; Mouse . PubMed: 22114177
  • Ming XF  et al. Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. J Am Heart Assoc 1:e000992 (2012). PubMed: 23130157
  • Jin G  et al. MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. EMBO J 30:2281-93 (2011). PubMed: 21572390
  • Wittschieber D  et al. Decreased RECK and Increased EMMPRIN expression in urothelial carcinoma of the bladder are associated with tumor aggressiveness. Pathobiology 78:123-31 (2011). PubMed: 21613799
  • Bialek J  et al. Relaxin enhances the collagenolytic activity and in vitro invasiveness by upregulating matrix metalloproteinases in human thyroid carcinoma cells. Mol Cancer Res 9:673-87 (2011). ICC/IF ; Human . PubMed: 21493587
  • Ferraro GB  et al. Membrane-type Matrix Metalloproteinase-3 Regulates Neuronal Responsiveness to Myelin through Nogo-66 Receptor 1 Cleavage. J Biol Chem 286:31418-24 (2011). PubMed: 21768085
  • Bernert B  et al. Hyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1). J Biol Chem 286:42349-59 (2011). WB . PubMed: 22016393
  • Rezvani HR  et al. Loss of epidermal hypoxia-inducible factor-1a accelerates epidermal aging and affects re-epithelialization in human and mouse. J Cell Sci 124:4172-83 (2011). WB ; Human . PubMed: 22193962
  • Triantafyllopoulou A  et al. Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci U S A 107:3012-7 (2010). WB ; Mouse . PubMed: 20133703
  • Agrawal V  et al. Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A 107:3351-5 (2010). IHC-P ; Mouse . PubMed: 19966310
  • Saha A  et al. Lack of an endogenous anti-inflammatory protein in mice enhances colonization of B16F10 melanoma cells in the lungs. J Biol Chem 285:10822-31 (2010). WB ; Mouse . PubMed: 20118237
  • Hawinkels LJ  et al. Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res 70:4141-50 (2010). WB, IHC-P ; Human . PubMed: 20424116
  • Miller JP  et al. Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease. Neuron 67:199-212 (2010). WB ; Human . PubMed: 20670829
  • Barnes BR  et al. Alterations in mRNA and protein levels of metalloproteinases-2, -9, and -14 and tissue inhibitor of metalloproteinase-2 responses to traumatic skeletal muscle injury. Am J Physiol Cell Physiol 297:C1501-8 (2009). PubMed: 19794148
  • Fromigué O  et al. Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. J Biol Chem 283:30549-56 (2008). ICC/IF ; Human . PubMed: 18757369

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