Overview

  • Product name
    Anti-MMP28 antibody [EP1341(2)]
    See all MMP28 primary antibodies
  • Description
    Rabbit monoclonal [EP1341(2)] to MMP28
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human MMP28 aa 450 to the C-terminus (Cysteine residue). The exact sequence is proprietary.
    Database link: Q9H239

  • Positive control
    • Human placenta, human testis lysate, recombinant protein fragment
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab175937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 62 kDa (predicted molecular weight: 59 kDa).
  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function
      Can degrade casein. Could play a role in tissues homeostasis and repair.
    • Tissue specificity
      Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytesis. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin.
    • Sequence similarities
      Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • Domain
      The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • Post-translational
      modifications
      The precursor is cleaved by a furin endopeptidase.
    • Cellular localization
      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • Epilysin antibody
      • Matrix metalloproteinase 28 antibody
      • Matrix metalloproteinase-28 antibody
      • MM 28 antibody
      • MM28 antibody
      • MMP 25 antibody
      • MMP 28 antibody
      • MMP-28 antibody
      • MMP25 antibody
      • MMP28 antibody
      • MMP28_HUMAN antibody
      see all

    Images

    • Anti-MMP28 antibody [EP1341(2)] (ab175937) at 1/1000 dilution + MMP-28 recombinant protein fragment at 0.01 µg

      Predicted band size: 59 kDa

    • All lanes : Anti-MMP28 antibody [EP1341(2)] (ab175937) at 1/1000 dilution

      Lane 1 : Human placenta lysate
      Lane 2 : Human testis lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 59 kDa

    References

    ab175937 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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