Overview

  • Product name

  • Description

    Goat polyclonal to MMP3
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Horse, Dog
  • Immunogen

    Synthetic peptide corresponding to Human MMP3 aa 459-473 (C terminal) (Cysteine residue). NP_002413.1
    Sequence:

    C-DPNAKKVTHTLKSNS


    Database link: P08254

  • Positive control

    • WB: Mouse eye lysate; human prostate lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab223666 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 54 kDa).

Target

  • Function

    Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
  • Sequence similarities

    Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • Domain

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • CHDS6 antibody
    • Matrix metalloproteinase 3 antibody
    • Matrix metalloproteinase 3 preproprotein antibody
    • Matrix metalloproteinase-3 antibody
    • MGC126102 antibody
    • MGC126103 antibody
    • MGC126104 antibody
    • MMP 3 antibody
    • MMP-3 antibody
    • MMP3 antibody
    • MMP3_HUMAN antibody
    • Proteoglycanase antibody
    • SL-1 antibody
    • SL1 antibody
    • STMY antibody
    • STMY1 antibody
    • STR1 antibody
    • Stromelisin 1 antibody
    • Stromelysin 1 antibody
    • Stromelysin 1 progelatinase antibody
    • Stromelysin-1 antibody
    • Transin 1 antibody
    • Transin-1 antibody
    see all

Images

  • Anti-MMP3 antibody (ab223666) at 0.3 µg/ml + mouse eye lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 54 kDa
    Observed band size: 60 kDa
    why is the actual band size different from the predicted?



    Primary incubation was 1 hour

  • Anti-MMP3 antibody (ab223666) at 0.2 µg/ml + human prostate lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 54 kDa
    Observed band size: 55 kDa why is the actual band size different from the predicted?



    Primary incubation was 1 hour

References

ab223666 has not yet been referenced specifically in any publications.

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