Recombinant Anti-MMP3 antibody [EP1186Y] (ab52915)

Rabbit recombinant monoclonal MMP3 antibody [EP1186Y]. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human. Cited in 47 publication(s). Independently reviewed in 3 review(s).

Publishing research using ab52915? Please let us know so that we can cite the reference in this datasheet.

ab52915 has been referenced in 54 publications.

  • Son YO  et al. RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family. Nat Commun 10:77 (2019). PubMed: 30622281
  • Zhang H  et al. Semaphorin 4A acts in a feed-forward loop with NF-?B pathway to exacerbate catabolic effect of IL-1ß on chondrocytes. Int Immunopharmacol 69:88-94 (2019). PubMed: 30685700
  • Chen W  et al. Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis. Int Immunopharmacol 71:259-266 (2019). PubMed: 30927736
  • Jiang Y  et al. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats. Evid Based Complement Alternat Med 2019:1908416 (2019). PubMed: 30915142
  • Ni L  et al. Proinflammatory macrophages promote degenerative phenotypes in rat nucleus pulpous cells partly through ERK and JNK signaling. J Cell Physiol 234:5362-5371 (2019). PubMed: 30367477
  • Ma S  et al. Corneal autophagy and ocular surface inflammation: A new perspective in dry eye. Exp Eye Res 184:126-134 (2019). PubMed: 31018117
  • Kang LJ  et al. 3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Br J Pharmacol 175:4295-4309 (2018). PubMed: 30152858
  • Chang JC  et al. SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. J Bone Miner Res 33:1105-1113 (2018). PubMed: 29377313
  • Fan M  et al. Dihydroartemisinin derivative DC32 attenuates collagen-induced arthritis in mice by restoring the Treg/Th17 balance and inhibiting synovitis through down-regulation of IL-6. Int Immunopharmacol 65:233-243 (2018). PubMed: 30336338
  • Zeng JJ  et al. Curcumin Inhibits Proliferation of Synovial Cells by Downregulating Expression of Matrix Metalloproteinase-3 in Osteoarthritis. Orthop Surg N/A:N/A (2018). PubMed: 30560591
  • Jeon J  et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med 22:57-66 (2018). WB . PubMed: 28782172
  • Liu X  et al. Protective effect of curcumin against ultraviolet A irradiation-induced photoaging in human dermal fibroblasts. Mol Med Rep 17:7227-7237 (2018). PubMed: 29568864
  • Ding SM  et al. The role of cancer-associated fibroblast MRC-5 in pancreatic cancer. J Cancer 9:614-628 (2018). WB ; Human . PubMed: 29483967
  • Choi MC  et al. Alleviation of Murine Osteoarthritis by Cartilage-Specific Deletion of I?B?. Arthritis Rheumatol 70:1440-1449 (2018). PubMed: 29604191
  • Yang Y  et al. Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-?B Pathway. Front Pharmacol 9:598 (2018). PubMed: 29928231
  • Tawiah A  et al. High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors. Am J Pathol 188:2025-2041 (2018). PubMed: 29935164
  • Ma C  et al. Specnuezhenide Decreases Interleukin-1ß-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats. Front Pharmacol 9:700 (2018). PubMed: 30050432
  • Li S  et al. Exposure to fermentation supernatant of Staphylococcus aureus accelerated dedifferentiation of chondrocytes and production of antimicrobial peptides. J Orthop Res N/A:N/A (2017). PubMed: 28513981
  • Son YO  et al. Estrogen-related receptor ? causes osteoarthritis by upregulating extracellular matrix-degrading enzymes. Nat Commun 8:2133 (2017). WB, IHC ; Human . PubMed: 29247173
  • Wei JL  et al. Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models. Arthritis Res Ther 19:280 (2017). PubMed: 29258611
  • Zhuang R  et al. CR6-interacting factor 1 inhibits invasiveness by suppressing TGF-ß-mediated epithelial-mesenchymal transition in hepatocellular carcinoma. Oncotarget 8:94759-94768 (2017). PubMed: 29212264
  • Hao XD  et al. De novo mutations of TUBA3D are associated with keratoconus. Sci Rep 7:13570 (2017). PubMed: 29051577
  • Juengel E  et al. HDAC inhibition as a treatment concept to combat temsirolimus-resistant bladder cancer cells. Oncotarget 8:110016-110028 (2017). IHC-P ; Human . PubMed: 29299126
  • Cunha C  et al. Joint analysis of IVD herniation and degeneration by rat caudal needle puncture model. J Orthop Res 35:258-268 (2017). IHC ; Rat . PubMed: 26610284
  • O'Callaghan J  et al. Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma. Hum Mol Genet 26:1230-1246 (2017). IHC ; Mouse . PubMed: 28158775
  • McKay TB  et al. Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro. PLoS One 12:e0176017 (2017). WB ; Human . PubMed: 28426715
  • Hu J  et al. BMSC paracrine activity attenuates interleukin-1ß-induced inflammation and apoptosis in rat AF cells via inhibiting relative NF-?B signaling and the mitochondrial pathway. Am J Transl Res 9:79-89 (2017). WB ; Rat . PubMed: 28123635
  • Cheng X  et al. Solute Carrier Family 39 Member 6 Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-Kinase Signaling, and Up-regulating Genes That Regulate Metastasis. Gastroenterology 152:1985-1997.e12 (2017). PubMed: 28209530
  • Zhao L  et al. Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ß-catenin signalling and GADD45G expression. J Cell Mol Med 20:842-54 (2016). WB ; Human . PubMed: 26843424
  • Peng C  et al. Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the avß6-ERK-Ets1 Signaling Pathway. Sci Rep 6:20500 (2016). PubMed: 26846153
  • Li C  et al. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. Nat Commun 7:11455 (2016). IHC (PFA fixed), WB . PubMed: 27126736
  • Usmani SE  et al. Context-specific protection of TGFa null mice from osteoarthritis. Sci Rep 6:30434 (2016). IHC-P ; Mouse . PubMed: 27457421
  • Jaako K  et al. Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro. J Cell Sci 129:3792-3802 (2016). PubMed: 27566163
  • Chen M  et al. Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon. Mediators Inflamm 2016:5359768 (2016). IHC . PubMed: 27478308
  • Van Hove I  et al. MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment. Int J Mol Sci 17:N/A (2016). WB, IHC ; Mouse . PubMed: 27809288
  • Lowin T  et al. The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets. J Inflamm (Lond) 13:15 (2016). PubMed: 27158245
  • Xu K  et al. Sp1 downregulates proinflammatory cytokine-induced catabolic gene expression in nucleus pulposus cells. Mol Med Rep 14:3961-8 (2016). PubMed: 27600876
  • Kim JH  et al. Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis. Proc Natl Acad Sci U S A 112:9424-9 (2015). PubMed: 26170306
  • Lowin T  et al. Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner. Arthritis Res Ther 17:321 (2015). ELISA . PubMed: 26567045
  • Zambirinis CP  et al. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med 212:2077-94 (2015). WB ; Human . PubMed: 26481685
  • Li J  et al. Prolyl-4-hydroxylase domain protein 2 controls NF-?B/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. J Biol Chem 290:7195-207 (2015). PubMed: 25635047
  • Xu K  et al. Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-?B and JNK inhibition. Int J Mol Med 36:661-8 (2015). PubMed: 26165348
  • Ma J  et al. Pachymic acid modified carbon nanoparticles reduced angiogenesis via inhibition of MMP-3. Int J Clin Exp Pathol 8:5464-70 (2015). PubMed: 26191251
  • Jakobs C  et al. AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis. PLoS One 10:e0131702 (2015). WB, IHC ; Mouse . PubMed: 26114879
  • De Groef L  et al. Matrix metalloproteinases in the mouse retina: a comparative study of expression patterns and MMP antibodies. BMC Ophthalmol 15:187 (2015). Mouse . PubMed: 26714639
  • Tran CM  et al. CCN2 suppresses catabolic effects of interleukin-1ß through a5ß1 and aVß3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. J Biol Chem 289:7374-87 (2014). WB . PubMed: 24464580
  • Ryu JH  et al. Hypoxia-inducible factor-2a is an essential catabolic regulator of inflammatory rheumatoid arthritis. PLoS Biol 12:e1001881 (2014). WB . PubMed: 24914685
  • Fang Y  et al. Gastroesophageal reflux activates the NF-?B pathway and impairs esophageal barrier function in mice. Am J Physiol Gastrointest Liver Physiol 305:G58-65 (2013). IHC ; Mouse . PubMed: 23639809
  • Van Hove I  et al. Matrix metalloproteinase-3 in the central nervous system: a look on the bright side. J Neurochem 123:203-16 (2012). ICC/IF ; Mouse . PubMed: 22862420
  • Alexander MR  et al. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J Clin Invest 122:70-9 (2012). IHC-P ; Mouse . PubMed: 22201681
  • Raaf L  et al. Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats. Mol Cell Biochem 347:63-70 (2011). WB ; Rat . PubMed: 20938722
  • Andersen K  et al. The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis. Dev Biol 352:181-90 (2011). WB ; Mouse . PubMed: 21195708
  • Ponnappan RK  et al. An organ culture system to model early degenerative changes of the intervertebral disc. Arthritis Res Ther 13:R171 (2011). WB, IHC-P ; Rat . PubMed: 22018279
  • Steude JS  et al. Mammographic Density and Matrix Metalloproteinases in Breast Tissue. Cancer Microenviron : (2009). IHC-P ; Human . PubMed: 20012240

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