MMPSI, Caspase-3/7 Inhibitor I, caspase 3 and 7 inhibitor (ab145046)

Overview

  • Product name

    MMPSI, Caspase-3/7 Inhibitor I, caspase 3 and 7 inhibitor
  • Description

    Selective caspase 3 and 7 inhibitor
  • Biological description

    Selective caspase 3 and 7 inhibitor (IC50 = 1.7 μM, caspase-3). Reduces ischemic-induced apoptosis (IC50 = 0.5 μM). Shows cardioprotective effects.
  • Purity

    > 98%
  • CAS Number

    220509-74-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Floyd DH  et al. Novel Anti-Apoptotic MicroRNAs 582-5p and 363 Promote Human Glioblastoma Stem Cell Survival via Direct Inhibition of Caspase 3, Caspase 9, and Bim. PLoS One 9:e96239 (2014). Read more (PubMed: 24805821) »
  • Limpachayaporn P  et al. Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7. Eur J Med Chem 64:562-78 (2013). Read more (PubMed: 23685941) »
  • Chapman JG  et al. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol 456:59-68 (2002). Read more (PubMed: 12450570) »

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