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  1. Link

    mms2-antibody-ab195589.pdf

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Epigenetics and Nuclear Signaling DNA / RNA DNA Damage & Repair DNA Damage Response Other
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Anti-MMS2 antibody (ab195589)

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  • Western blot - Anti-MMS2 antibody (ab195589)

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Primary

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Secondary

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Protein

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  • Datasheet
  • References
  • Protocols

Overview

  • Product name

    Anti-MMS2 antibody
    See all MMS2 primary antibodies
  • Description

    Rabbit polyclonal to MMS2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human MMS2 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q15819

  • Positive control

    • HeLa and fetal brain lysate.
  • General notes

     This product was previously labelled as Ube2v2, MMS2

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.4
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Damage & Repair
    • DNA Damage Response
    • Other
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteasome / Ubiquitin
    • Ubiquitin E3 Enzymes
    • RING Finger E3 Ligase
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Ubiquitin ligases
    • Epigenetics and Nuclear Signaling
    • Ubiquitin & Ubiquitin Like Modifiers
    • E2 Ubiquitin Conjugating Enzymes
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteasome / Ubiquitin
    • Ubiquitin E2 Enzymes

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab150035)
    • HeLa whole cell lysate (ab29545)
  • Recombinant Protein

    • Recombinant Human MMS2 protein (ab167920)
  • Related Products

    • Recombinant Human MMS2 protein (ab167920)

Applications

Our Abpromise guarantee covers the use of ab195589 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50.
WB 1/200 - 1/1000. Predicted molecular weight: 16 kDa.

Target

  • Function

    Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
  • Tissue specificity

    Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.
  • Sequence similarities

    Belongs to the ubiquitin-conjugating enzyme family.
  • Target information above from: UniProt accession Q15819 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 7336 Human
    • Entrez Gene: 100503412 Mouse
    • Entrez Gene: 70620 Mouse
    • Entrez Gene: 287927 Rat
    • Omim: 603001 Human
    • SwissProt: Q15819 Human
    • SwissProt: Q9D2M8 Mouse
    • SwissProt: Q7M767 Rat
    • Unigene: 491695 Human
    • Unigene: 235407 Mouse
    • Unigene: 390775 Mouse
    • Unigene: 3933 Rat
    see all
  • Alternative names

    • 1 alpha 25 dihydroxyvitamin D3 inducible antibody
    • DDVit 1 antibody
    • DDVIT1 antibody
    • EDAF-1 antibody
    • EDAF1 antibody
    • EDPF-1 antibody
    • EDPF1 antibody
    • Enterocyte differentiation associated factor EDAF 1 antibody
    • Enterocyte differentiation promoting factor antibody
    • Enterocyte differentiation-associated factor 1 antibody
    • Enterocyte differentiation-promoting factor 1 antibody
    • Methyl methanesulfonate sensitive 2 antibody
    • MMS 2 antibody
    • MMS2 antibody
    • MMS2 homolog antibody
    • UB2V2_HUMAN antibody
    • UBE2V 2 antibody
    • UBE2V2 antibody
    • Ubiquitin conjugating enzyme E2 variant 2 antibody
    • Ubiquitin conjugating enzyme E2v2 antibody
    • Ubiquitin-conjugating enzyme E2 variant 2 antibody
    • UEV 2 antibody
    • UEV2 antibody
    • Vitamin D3 inducible protein antibody
    • Vitamin D3-inducible protein antibody
    see all

Images

  • Western blot - Anti-MMS2 antibody (ab195589)
    Western blot - Anti-MMS2 antibody (ab195589)
    All lanes : Anti-MMS2 antibody (ab195589) at 1/250 dilution

    Lane 1 : HeLa lysate
    Lane 2 : Human Fetal brain lysate

    Predicted band size: 16 kDa

Protocols

  • Western blot protocols
  • Immunocytochemistry & immunofluorescence protocols

Datasheets and documents

    • Datasheet
  • References

    ab195589 has not yet been referenced specifically in any publications.

    Publishing research using ab195589? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

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