Overview

  • Product name

  • Description

    Rabbit polyclonal to MNDA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human MNDA aa 85-173.
    Sequence:

    EKSKVAKKIKTQEKAPVKKINQEEVGLAAPAPTARNKLTSEARGRIPVAQ KRKTPNKEKTEAKRNKVSQEQSKPPGPSGASTSAAVDHP


    Database link: P41218

  • Positive control

    • ICC/IF: NB-4 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab221947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

Target

  • Function

    May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
  • Tissue specificity

    Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.
  • Sequence similarities

    Contains 1 DAPIN domain.
    Contains 1 HIN-200 domain.
  • Domain

    Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
  • Cellular localization

    Nucleus. Cytoplasm. Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
  • Information by UniProt
  • Database links

  • Alternative names

    • MNDA antibody
    • MNDA_HUMAN antibody
    • Myeloid cell nuclear differentiation antigen antibody
    • OTTHUMP00000024384 antibody
    • PYHIN3 antibody
    see all

Images

  • PFA-fixed, Triton X-100 permeabilized NB-4 cells stained for MNDA (green) using ab221947 at 4 µg/ml in ICC/IF. 

References

ab221947 has not yet been referenced specifically in any publications.

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