Overview

  • Product name
    MnTBAP chloride, Superoxide dismutase (SOD) mimetic
  • Description
    Cell-permeable superoxide dismutase (SOD) mimetic
  • Biological description
    Cell-permeable SOD mimetic. Potent peroxynitrite scavenger. Does not scavenge NO. Shows anti-inflammatory effects and reduces oxidative injury in vivo. Reduces ROS and shows a neuroprotective effect in spinal cord injury.
  • General notes

    Dissolve at 0.1 M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.

  • CAS Number
    55266-18-7
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    [5,10,15,20-Tetrakis(4-carboxyphenyl)-21H,23H-porphine]manganese(III)
    chloride
  • Molecular weight
    879.15
  • Molecular formula
    C48H28ClMnN4O8
  • PubChem identifier
    16760566
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC(=CC=C1C2=C3C=CC(=C(C4=NC(=C(C5=CC=C([N-]5)C(=C6C=CC2=N6)C7=CC=C(C=C7)C(=O)O)C8=CC=C(C=C8)C(=O)O)C=C4)C9=CC=C(C=C9)C(=O)O)[N-]3)C(=O)O.[Cl-].[Mn+3]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Liu D  et al. Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone. BMC Neurosci 14:23 (2013). Read more (PubMed: 23452429) »
  • Schrammel A  et al. Cardiac oxidative stress in a mouse model of neutral lipid storage disease. Biochim Biophys Acta 1831:1600-8 (2013). Read more (PubMed: 23867907) »
  • Suresh MV  et al. The protective role of MnTBAP in oxidant-mediated injury and inflammation in a rat model of lung contusion. Surgery 154:980-90 (2013). Read more (PubMed: 24139490) »
  • Batinic-Haberle I  et al. Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radic Biol Med 46:192-201 (2009). Read more (PubMed: 19007878) »

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